4.1 Article

Early mortality continues to be a barrier to excellent survival in childhood acute promyelocytic leukemia: a retrospective study of 62 patients spanning 17 years

Related references

Note: Only part of the references are listed.
Article Oncology

Outcome and complications of pediatric acute promyelocytic leukemia in Bangladesh

Eshita Reza Khan et al.

Summary: The study in Bangladesh on pediatric APL revealed promising outcomes with 85% of patients achieving remission after induction therapy, and a 3-year overall survival rate of 70%. Neutropenic sepsis was identified as the most common complication and leading cause of mortality in these patients.

PEDIATRIC HEMATOLOGY AND ONCOLOGY (2022)

Article Oncology

Assessment of Arsenic Trioxide and All-trans Retinoic Acid for the Treatment of Pediatric Acute Promyelocytic Leukemia A Report From the Children's Oncology Group AAML1331 Trial

Matthew A. Kutny et al.

Summary: The study showed that pediatric patients with standard-risk APL benefited from ATRA and arsenic trioxide therapy, while patients with high-risk APL also had positive outcomes with a novel treatment regimen that included idarubicin during induction therapy only. The 2-year EFS estimates were noninferior to the historical comparator group, and the regimen had advantages including shorter treatment duration and fewer adverse events.

JAMA ONCOLOGY (2022)

Article Oncology

Retrospective single-center experience with OEPA/COPDAC and PET-CT based strategy for pediatric Hodgkin lymphoma in a LMIC setting

Achanya Palayullakandi et al.

Summary: The study retrospectively analyzed the outcome of using the Euronet PHL-C1 protocol for treating Hodgkin lymphoma in India. The results showed that the OEPA/COPDAC regimen and PET-CT assessment allowed for therapy reduction, including radiotherapy. However, treatment-related mortality and febrile neutropenia were concerning issues.

PEDIATRIC HEMATOLOGY AND ONCOLOGY (2022)

Article Hematology

An Outcome Analysis of Childhood Acute Promyelocytic Leukemia Treated with Atra and Arsenic Trioxide, and Limited Dose Anthracycline

Naeem Jabbar et al.

Summary: The study aimed to evaluate the outcome of children with APL using ATO and ATRA, showing that most patients achieved molecular remission after chemotherapy with a high survival rate of 95%. Patients in the high-risk group had inferior outcomes compared to those in the standard-risk group.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2021)

Article Oncology

Arsenic Combined With All-Trans Retinoic Acid for Pediatric Acute Promyelocytic Leukemia: Report From the CCLG-APL2016 Protocol Study

Huyong Zheng et al.

Summary: A multicenter trial in China found that arsenic combined with ATRA is effective and safe in treating pediatric patients with APL, although long-term follow-up is still necessary.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Early Mortality in Children and Adolescents with Acute Promyelocytic Leukemia: Experience of the Boldrini Children's Center

Amilcar C. de Azevedo et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2020)

Review Pediatrics

Advances in Pediatric Acute Promyelocytic Leukemia

Shannon E. Conneely et al.

CHILDREN-BASEL (2020)

Article Hematology

Predictive factors of fatal bleeding in acute promyelocytic leukemia

Simon Mantha et al.

THROMBOSIS RESEARCH (2018)

Article Hematology

Mechanisms and management of coagulopathy in acute promyelocytic leukemia

Sachin David et al.

THROMBOSIS RESEARCH (2018)

Article Medicine, Research & Experimental

Hyperfibrinolysis Is an Important Cause of Early Hemorrhage in Patients with Acute Promyelocytic Leukemia

Yu-Hua Song et al.

MEDICAL SCIENCE MONITOR (2018)

Article Hematology

Acute Promyelocytic Leukemia in Children: A Single Centre Experience from Turkey

Tekin Aksu et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2018)

Article Pediatrics

SIOP ABSTRACTS

PEDIATRIC BLOOD & CANCER (2018)

Article Hematology

Acute Promyelocytic Leukemia in Children and Adolescents

Eytan M. Stein et al.

ACTA HAEMATOLOGICA (2014)

Article Oncology

Hodgkin Lymphoma in Children: Experience in a Tertiary Care Centre in India

Amita Trehan et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2013)

Review Hematology

The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia

Karen A. Breen et al.

BRITISH JOURNAL OF HAEMATOLOGY (2012)

Article Hematology

Treatment advances have not improved the early death rate in acute promyelocytic leukemia

James Scott McClellan et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)

Review Hematology

The Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia: Experience of the Pethema Group and Review of the Literature

Pau Montesinos et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2011)