4.5 Article

Genetic profile identification and clinicopathologic characteristics analysis of the thyroid-like low-grade nasopharyngeal papillary adenocarcinoma

Journal

PATHOLOGY RESEARCH AND PRACTICE
Volume 236, Issue -, Pages -

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.prp.2022.153980

Keywords

Thyroid like low-grade papillary adenocarci noma of nasopharynx; Total exon sequencing; Immunochemistry; Clinicopathological features; Genomic characteristics

Categories

Funding

  1. Changsha Natural Science Foundation [kq:2007071]
  2. Changsha Administration of Science & Technology, Hunan, China

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In this study, the genomic characteristics of four cases of TL-LGNPPA were reported, shedding light on the clinical pathological features of this tumor. It was found that 41 mutations and two copy number variations were present, but no typical driver mutations were identified. Additionally, no microsatellite instability and HLA loss of heterozygosity were found. This study is the first to reveal the genetic underpinnings of this rare tumor.
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignancy bearing histomorphological similarities to papillary thyroid carcinoma with good prognosis. It's important to distinguish TL-LGNPPA from other papillary tumors including nasopharyngeal papillary adenocarcinoma (NPPA), metastatic and ectopic papillary thyroid cancer, and metastasized adenocarcinomas, etc. To date, only 48 cases of TL-LGNPPA have been reported in the English literatures. Here, we reported the genomic charac-teristics of additional 4 cases and reviewed other reports to clarify the clinicopathological features of this tumor. In this study, 41 mutations were detected by whole-exome sequencing, but no typical driver mutations were found. Two sample with Copy Number Variations (CNV) were found (7 q22. 17 q12), of which the segment spanned the regions of RASA4, POLR2J2, SPDYE2, CCL3, CCL4, etc. Additionally, no MSI and HLA LOH were found. To our knowledge, we are the first to reveal the genetic underpinnings of this rare tumor. The clinico-pathological features of TL-LGNPPA were characterized, shedding more light on the essential difference between TL-LGNPPA with other papillary tumors.

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