4.6 Article

Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Yonghyun Lee et al.

Summary: The gastrointestinal tract plays a crucial role in both local and systemic diseases, influenced by factors like the mucosal immune system, intestinal barrier, and gut microbiota. Selective drug delivery for oral vaccines, immune tolerance, and inflammatory diseases faces challenges due to the physiological and biological barriers of the GIT. Advances in oral nanomedicine offer potential solutions for overcoming these barriers and effectively targeting treatments to the GIT.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Applied

Ultrasonicated resveratrol loaded starch nanocapsules: Characterization, bioactivity and release behaviour under in-vitro digestion

Mudasir Ahmad et al.

Summary: The study involved nano-encapsulating resveratrol in various starch sources to enhance its bioavailability and bioactivity. The nano-capsules showed good encapsulation efficiency, particle size, and zeta potential, with improved anti-diabetic and anti-obesity properties compared to free resveratrol.

CARBOHYDRATE POLYMERS (2021)

Article Chemistry, Multidisciplinary

Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?

Samantha V. Llewellyn et al.

Summary: The study shows that engineered nanomaterials may undergo identity transformation after passing through multiple physiological compartments, with pre-treatments enhancing the physiological relevance of in vitro testing. However, pre-treatments are recommended for only specific ENMs.

SMALL (2021)

Article Environmental Sciences

Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine

Mathias Busch et al.

Summary: The study found that there were no acute toxic effects observed in the model of the healthy intestine after exposure to polystyrene (PS) or polyvinyl chloride (PVC) particles. However, during active inflammatory processes, exposure to PVC particles was found to increase the release of IL-1 beta and cause loss of epithelial cells.

ENVIRONMENTAL RESEARCH (2021)

Article Toxicology

The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs

Yongliang Zhang et al.

Summary: Food-grade titanium dioxide nanoparticles have a certain impact on the intestinal epithelial structure, but do not affect intestinal barrier function. Co-exposure to TiO2 and LPS enhances intestinal barrier function without causing notable inflammatory responses, and there is an antagonistic effect between TiO2 NPs and LPS.

PARTICLE AND FIBRE TOXICOLOGY (2021)

Article Chemistry, Analytical

Caco-2 in vitro model of human gastrointestinal tract for studying the absorption of titanium dioxide and silver nanoparticles from seafood

Maria Vanesa Taboada-Lopez et al.

Summary: Titanium dioxide nanoparticles and silver nanoparticles are extensively used in various industries and may unintentionally enter the human gastrointestinal tract through food and water. In vitro digestion studies were conducted to determine the bioaccessibility of these nanoparticles in shellfish, as well as their transport through the gastrointestinal epithelial barrier model.

TALANTA (2021)

Article Environmental Sciences

Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation

Xiaoqiong Cao et al.

Summary: The study revealed that food additives TiO2 and SiO2 can increase the translocation of pesticide boscalid, affecting gene expression in intestinal epithelial cells and potentially weakening cell junctions and intercellular adhesion, resulting in dysregulation of paracellular transport.

NANOIMPACT (2021)

Article Environmental Sciences

Effect of food on orally-ingested titanium dioxide and zinc oxide nanoparticle behaviors in simulated digestive tract

Pengfei Zhou et al.

Summary: The study demonstrates the importance of considering the impact of food matrices on the fate and toxicity of nanoparticles after oral ingestion, as different food conditions can result in varied behaviors of nanoparticles. Understanding the effect of food is crucial for assessing the environmental fate and biological effects of nanoparticles.

CHEMOSPHERE (2021)

Article Food Science & Technology

Tannic acid-fortified zein-pectin nanoparticles: Stability, properties, antioxidant activity, and in vitro digestion

Xiao Liang et al.

Summary: This research successfully loaded tannic acid into zein nanoparticles and coated them with anionic pectin, forming core-shell nanoparticles. The nanoparticles showed resistance to flocculation under various conditions, preserved the antioxidant capacity of tannic acid, and released the compound primarily in the small intestine. These findings suggest that pectin-coated zein nanoparticles could be effective encapsulation and delivery systems for hydrophilic polyphenols.

FOOD RESEARCH INTERNATIONAL (2021)

Article Multidisciplinary Sciences

Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT116

Giulia Vecchiotti et al.

Summary: This study evaluated the interaction between PNPs and colorectal adenocarcinoma cells, assessing metabolic activity, cytotoxic potential and genotoxicity. The results showed moderate toxicity of PNPs in terms of ROS production and DNA damage, leading to the need for further studies on different cell lines to fully understand the impact of environmental pollution on human health.

PLOS ONE (2021)

Article Immunology

Do Engineered Nanomaterials Affect Immune Responses by Interacting With Gut Microbiota?

Mingxing Tang et al.

Summary: While engineered nanomaterials (ENMs) do not seem to have direct detrimental effects on immunity, they may indirectly affect intestinal immunity by modulating the gut microbiota. The gut microbiota could play a crucial role in reshaping the immune response in the intestine upon exposure to ENMs.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

In vitro digestion of food grade TiO2 (E171) and TiO2 nanoparticles: physicochemical characterization and impact on the activity of digestive enzymes

William Dudefoi et al.

Summary: The study found that two types of food grade TiO2 samples and one nano-sized TiO2 sample could form large agglomerates in digestive fluids, but had limited impact on the overall digestion of carbohydrates and proteins. Under salivary conditions, TiO2 had an inhibitory effect on the enzymatic activity of alpha-amylase, which was reduced to almost 10% in the intestinal fluid.

FOOD & FUNCTION (2021)

Article Biochemistry & Molecular Biology

Fate of hydroxyapatite nanoparticles during dynamic in vitro gastrointestinal digestion: the impact of milk as a matrix

Kinley Choki et al.

Summary: This study found that the dissolution of nHA during in vitro gastric digestion involved a rapid early stage and a slower later stage, with the addition of skim milk significantly retarding the dissolution rate of nHA. However, there was no sign of nHA recrystallization in the intestinal phase. X-ray diffraction analysis showed the breakdown of the crystalline structure of nHA and the formation of potentially new calcium phosphate phases during digestion.

FOOD & FUNCTION (2021)

Article Toxicology

Evaluation of the Dermal Toxicity of InZnP Quantum Dots Before and After Accelerated Weathering: Toward a Safer-By-Design Strategy

Fanny Dussert et al.

Summary: The study found that both fresh and aged QDs accumulate in human primary keratinocytes, causing toxicity, particularly with aged QDs leading to cytotoxicity and genotoxicity. The expression of proteins involved in zinc homeostasis, cell redox response, and inflammation were significantly altered. Adding a second shell can reduce toxicity, making it a promising safer-by-design strategy.

FRONTIERS IN TOXICOLOGY (2021)

Article Toxicology

In vitro copper oxide nanoparticle toxicity on intestinal barrier

Alessia Bertero et al.

Summary: The study compared the effects of commercial and sonochemically synthesized CuO NPs on the Caco-2 cell barrier, finding that sono CuO NPs induced a TEER decrease after basolateral exposure, while commercial CuO NPs did not affect TEER values after apical exposure. In addition, sono CuO NPs also triggered the release of interleukin-8, while apical exposure to commercial and CuOw NPs resulted in significant alterations to specific biomarkers of protein oxidative damage.

JOURNAL OF APPLIED TOXICOLOGY (2021)

Article Engineering, Biomedical

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

Nicholas G. Lamson et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Article Chemistry, Applied

Low-density polyethylene films incorporated with silver nanoparticles to promote antimicrobial efficiency in food packaging

Sabrina da Costa Brito et al.

FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL (2020)

Article Biochemistry & Molecular Biology

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

Mingxi Jia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres

I. Milto et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Chemistry, Medicinal

Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Saeko Tada-Oikawa et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2020)

Article Chemistry, Analytical

Nanoparticle Digestion Simulator Reveals pH-Dependent Aggregation in the Gastrointestinal Tract

Jia H. Shi et al.

ANALYTICAL CHEMISTRY (2020)

Article Agriculture, Multidisciplinary

Analysis of cerium oxide and copper oxide nanoparticles bioaccessibility from radish usingSP-ICP-MS

Maria Hayder et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

Review Chemistry, Multidisciplinary

Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology

Magdiel Inggrid Setyawati et al.

SMALL (2020)

Article Multidisciplinary Sciences

Comparing the permeability of human and porcine small intestinal mucus for particle transport studies

Lukasz Krupa et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

Miaorong Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Chemistry, Applied

Loading of fish oil into nanocarriers prepared through gelatin-gum Arabic complexation

Rahimeh Esfahani et al.

FOOD HYDROCOLLOIDS (2019)

Article Biochemistry & Molecular Biology

Pro- and anti-oxidant properties of near-infrared (NIR) light responsive carbon nanoparticles

Ida Kokalari et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Toxicology

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier

Graziano Colombo et al.

JOURNAL OF APPLIED TOXICOLOGY (2019)

Article Chemistry, Physical

Formation and properties of amorphous magnesium-calcium phosphate particles in a simulated intestinal fluid

Rita Gelli et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

Article Multidisciplinary Sciences

Polymeric nanoparticles as an alternative for application of gibberellic acid in sustainable agriculture: a field study

Anderson do Espirito Santo Pereira et al.

SCIENTIFIC REPORTS (2019)

Article Nanoscience & Nanotechnology

In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels

Miguel Xavier et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Immunology

Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis

Ruibing Yang et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biotechnology & Applied Microbiology

Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells

Marie Dorier et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2019)

Article Multidisciplinary Sciences

Reversibly pH-responsive gold nanoparticles and their applications for photothermal cancer therapy

Sanghak Park et al.

SCIENTIFIC REPORTS (2019)

Review Nanoscience & Nanotechnology

Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota

Hans Bouwmeester et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2018)

Article Chemistry, Physical

Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles

Jinping Wang et al.

CHEMISTRY OF MATERIALS (2018)

Article Pharmacology & Pharmacy

Titanium dioxide nanoparticle–protein interaction explained by docking approach

Shivendu Ranjan et al.

International Journal of Nanomedicine (2018)

Article Chemistry, Applied

Incorporation of Metallic Nanoparticles into Cosmetic Preparations and Assessment of Their Physicochemical and Utility Properties

Jolanta Pulit-Prociak et al.

JOURNAL OF SURFACTANTS AND DETERGENTS (2018)

Article Chemistry, Multidisciplinary

Structure and Interaction of Nanoparticle-Protein Complexes

Sugam Kumar et al.

LANGMUIR (2018)

Article Nanoscience & Nanotechnology

Preparation and characterization of hydroxyapatite nanoparticles carrying insulin and gallic acid for insulin oral delivery

Yuxiao Zhang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Toxicology

Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs

Ikjot Singh Sohal et al.

PARTICLE AND FIBRE TOXICOLOGY (2018)

Article Biotechnology & Applied Microbiology

Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid

Isabela Angeli de Lima et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Article Biophysics

Interaction of nanoparticles with biological systems

Peter Gehr

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

Review Immunology

Intestinal Dendritic Cells in Health and Gut Inflammation

Andrew J. Stagg

FRONTIERS IN IMMUNOLOGY (2018)

Review Critical Care Medicine

Tight junction structure, function, and assessment in the critically ill: a systematic review

David Vermette et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2018)

Article Engineering, Environmental

Effect of Protein Corona on Silver Nanoparticle Stabilization and Ion Release Kinetics in Artificial Seawater

Maja Levak et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Pharmacology & Pharmacy

Polyarginine nanocapsules: A versatile nanocarrier with potential in transmucosal drug delivery

Ana Gonzalez-Paredes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Review Gastroenterology & Hepatology

Regulation of intestinal permeability: The role of proteases

Hanne Van Spaendonk et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Pharmacology & Pharmacy

Mesoporous carbon nanomaterials in drug delivery and biomedical application

Qinfu Zhao et al.

DRUG DELIVERY (2017)

Review Biochemistry & Molecular Biology

Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery

Fahima Dilnawaz

CURRENT MEDICINAL CHEMISTRY (2017)

Article Environmental Sciences

Detection and dissolution of needle-like hydroxyapatite nanomaterials in infant formula

Jared J. Schoepf et al.

NANOIMPACT (2017)

Article Chemistry, Multidisciplinary

Inhaled Nanoparticles Accumulate at Sites of Vascular Disease

Mark R. Miller et al.

ACS NANO (2017)

Article Chemistry, Physical

Mechanism of hard-nanomaterial clearance by the liver

Kim M. Tsoi et al.

NATURE MATERIALS (2016)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Biochemical Research Methods

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

Stefka Tyanova et al.

NATURE PROTOCOLS (2016)

Article Chemistry, Multidisciplinary

Protein corona-induced modification of silver nanoparticle aggregation in simulated gastric fluid

Andrew P. Ault et al.

ENVIRONMENTAL SCIENCE-NANO (2016)

Article Materials Science, Biomaterials

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

Abhilash Sasidharan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Article Materials Science, Biomaterials

Biocorona Bound Gold Nanoparticles Augment Their Hematocompatibility Irrespective of Size or Surface Charge

Abhilash Sasidharan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Article Pharmacology & Pharmacy

Lipid nanoparticles enhance the efficacy of chemotherapy in primary and metastatic human osteosarcoma cells

Yolanda Gonzalez-Fernandez et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2015)

Article Chemistry, Multidisciplinary

Cellulose nanocrystals with tunable surface charge for nanomedicine

Zeinab Hosseinidoust et al.

NANOSCALE (2015)

Article Multidisciplinary Sciences

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Caroline A. Lindemans et al.

NATURE (2015)

Article Chemistry, Medicinal

In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract

Vincent Jannin et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2015)

Article Biochemical Research Methods

Optimized ferrozine-based assay for dissolved iron

Thomas M. Jeitner

ANALYTICAL BIOCHEMISTRY (2014)

Review Food Science & Technology

Specificity of Infant Digestive Conditions: Some Clues for Developing Relevant In Vitro Models

Claire Bourlieu et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2014)

Article Public, Environmental & Occupational Health

Dermal exposure potential from textiles that contain silver nanoparticles

Aleksandr B. Stefaniak et al.

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2014)

Article Chemistry, Multidisciplinary

Dissolution, Agglomerate Morphology, and Stability Limits of Protein-Coated Silver Nanoparticles

Matthew N. Martin et al.

LANGMUIR (2014)

Article Food Science & Technology

A novel preservation technique applied to fiordilatte cheese

A. Conte et al.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2013)

Article Nanoscience & Nanotechnology

Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model

Agata P. Walczak et al.

NANOTOXICOLOGY (2013)

Review Nanoscience & Nanotechnology

Bridge over troubled waters: understanding the synthetic and biological identities of engineered nanomaterials

Bengt Fadeel et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

Cyproterone Synthesis, Recognition and Controlled Release by Molecularly Imprinted Nanoparticle

Ebadullah Asadi et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2012)

Article Medicine, Research & Experimental

Screening of Budesonide Nanoformulations for Treatment of Inflammatory Bowel Disease in an Inflamed 3D Cell-Culture Model

Fransisca Leonard et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2012)

Article Chemistry, Multidisciplinary

The Evolution of the Protein Corona around Nanoparticles: A Test Study

Martin Lundqvist et al.

ACS NANO (2011)

Review Pathology

Epithelial Barriers in Homeostasis and Disease

Amanda M. Marchiando et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Chemistry, Multidisciplinary

What the Cell Sees in Bionanoscience

Dorota Walczyk et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Nanoscience & Nanotechnology

Physico-chemical features of engineered nanoparticles relevant to their toxicity

Bice Fubini et al.

NANOTOXICOLOGY (2010)

Review Biochemistry & Molecular Biology

Mechanism of cytokine modulation of epithelial tight junction barrier

Rana Al-Sadi et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

Article Pharmacology & Pharmacy

Microparticle transport in the human intestinal M cell model

Yin Hwa Lai et al.

JOURNAL OF DRUG TARGETING (2008)

Article Gastroenterology & Hepatology

Changes in the expression of claudins in active ulcerative colitis

Tadayuki Oshima et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Metallurgy & Metallurgical Engineering

Degradation mechanisms of poly (lactic-co-glycolic acid) films in vitro under static and dynamic environment

Huang Ying-ying et al.

TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA (2006)

Article Chemistry, Multidisciplinary

Magnetically responsive polymeric microparticles for oral delivery of protein drugs

JJ Cheng et al.

PHARMACEUTICAL RESEARCH (2006)

Review Multidisciplinary Sciences

Toxic potential of materials at the nanolevel

A Nel et al.

SCIENCE (2006)