Journal
PAIN
Volume 164, Issue 2, Pages E103-E115Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/j.pain.0000000000002709
Keywords
Primary sensory neurons; TRPV1; TRPV2; Mechanical allodynia; Heat hyperalgesia; Burn injury
Categories
Ask authors/readers for more resources
Tissue injuries, including burns, release intracellular molecules and induce inflammatory reactions, leading to persistent pain. This study reveals that 18:0 LPC, a lysophosphatidylcholine, plays a significant role in burn injury-induced pain. It activates pain-sensing neurons and causes hypersensitivities through the transient receptor potential ion channel. These findings have implications for improving patient care.
Tissue injuries, including burns, are major causes of death and morbidity worldwide. These injuries result in the release of intracellular molecules and subsequent inflammatory reactions, changing the tissues' chemical milieu and leading to the development of persistent pain through activating pain-sensing primary sensory neurons. However, the majority of pain-inducing agents in injured tissues are unknown. Here, we report that, amongst other important metabolite changes, lysophosphatidylcholines (LPCs) including 18:0 LPC exhibit significant and consistent local burn injury-induced changes in concentration. 18:0 LPC induces immediate pain and the development of hypersensitivities to mechanical and heat stimuli through molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1, and member 2 at least partly via increasing lateral pressure in the membrane. As levels of LPCs including 18:0 LPC increase in other tissue injuries, our data reveal a novel role for these lipids in injury-associated pain. These findings have high potential to improve patient care.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available