Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2022, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2022/3910116
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Funding
- Xiamen Marine Scientific and Technological Achievements Transformation and Industrialization Demonstration Project [18CYY026HJ13]
- Major Science and Technology Project of Fujian Province [2020NZ012010]
- Key Project of the Natural Science Foundation of Fujian Province [2020J02032]
- Double First-Class Construction Plan of Fujian Agriculture and Forestry University [KSYLX013]
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Insulin resistance plays a major role in the development of type 2 diabetes. This study found that a functional formulation called SFFs, derived from Spirulina platensis, Grifola frondosa, Panax ginseng, and chromium-rich yeast, can improve glycolipid metabolism disorder in mice. SFFs not only improve metabolic function and reduce inflammation, but also promote tissue regeneration and regulate intestinal microbes. Additionally, SFFs activate the INS/PI3K/GLUT-4 signaling pathway, which is important for glucose uptake and metabolism.
Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects. Therefore, there is an urgent need to search for safe and natural foods that do not cause adverse effects as alternatives to commercial drugs. In this study, the active substances from Spirulina platensis, Grifola frondosa, Panax ginseng, and chromium-rich yeast were used to obtain Spirulina functional formulations (SFFs), and its therapeutic effects on mice with glycolipid metabolism disorder (GLD) were investigated. Results showed that SFFs not only improved glycolipid metabolism and reduced inflammation in mice with GLD but also showed good regenerative effects on the liver, jejunum, and cecum tissues. Moreover, SFFs could inhibit the growth of harmful microbes in the intestine and promote the proliferation of beneficial bacteria, thereby promoting the production of short-chain fatty acids and further regulating GLD. Additionally, SFFs significantly increased the expression of INS, INSR, IRS-1, PI3K, AKT-1, and GLUT-4 genes and significantly decreased that of GSK-3 beta in the INS/PI3K/GLUT-4 signaling pathway. Therefore, the findings of this study suggest that SFFs can be further developed as a new class of therapeutic agents against GLD.
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