Synthesis of 5α,6-Dihydroveragranines A and B

The 5 alpha,6-dihydro congeners of veragranines A and B, two steroidal alkaloids with an unprecedented hexacyclic skeleton and potent analgesic effects, were synthesized from hecogenin acetate within six steps. This work enables quick access to the hexacyclic skeleton and is amendable to prepare other D -ring-modified congeners.

Automated summary

The novel congeners 5 alpha,6-dihydro of veragranines A and B, with unprecedented hexacyclic skeleton and potent analgesic effects, were synthesized in six steps from hecogenin acetate. This method provides a quick access to the hexacyclic skeleton and can be utilized for preparing other D-ring modified congeners.