Journal
ORGANIC LETTERS
Volume 24, Issue 32, Pages 6093-6098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02481
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Funding
- National Institute of Health (NIH) [R01GM135603]
- Allergan Research Fellowship
- UCI Dissertation Fellowship
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A nickel-catalyzed intramolecular conjunctive cross-electrophile coupling reaction has been developed for the synthesis of 3,5-vicinal carbocyclic rings found in various biologically active compounds and natural products. Mechanistic experiments suggest that the reaction proceeds through alkyl iodides formed in situ, initiates at the secondary electrophilic center, and proceeds via radical intermediates.
A nickel-catalyzed intramolecular conjunctive cross-electrophile coupling reaction has been established. This method enables the synthesis of 3,5-vicinal carbocyclic rings found in numerous biologically active compounds and natural products. We provide mechanistic experiments that indicate this reaction proceeds through alkyl iodides formed in situ, initiates at the secondary electrophilic center, and proceeds through radical intermediates.
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