Journal
ORGANIC LETTERS
Volume 24, Issue 25, Pages 4670-4674Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01818
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Funding
- NSFC [21971026, 22171028]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
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A highly efficient rhodium-catalyzed reaction has been developed for the atroposelective synthesis of axially chiral C2-arylindoles. The reaction proceeds under mild conditions using only 1 mol % of Rh-2(S-PTTL)(4) without the need for chelation group.
A highly efficient rhodium-catalyzed formal C-H insertion reaction between indoles and 1-diazonaphthoquinones has been established, providing a novel protocol for the atroposelective synthesis of axially chiral C2-arylindoles (up to 99:1 er) under mild reaction conditions. Typically, only 1 mol % of Rh-2(S-PTTL)(4) is used and the chelation group is not needed for this conversion.
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