Journal
ORGANIC LETTERS
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02240
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- Science and Technology Department of Guizhou Province [QKH 20201Z076, QKHJCZK[2021]YB569, QKHZC [2020]4Y203,, QKHJC-ZK[2022] YB293, QKHPTRC [2020]5008]
- National Natural Science Foundation of China (NSFC) [82060631, U1812403, 81760630, 31960087, 82160808, 81872772, 81960546]
- 13th Batch of Outstanding Young Scientific and Technological Talents in Guizhou Province [QKHPTRC [2021]5633]
- High-level Innovative Talents in Guizhou Province
- Cultivation Project of National Natural Science Foundation of Guizhou Medical University
- Light of the West Talent Cultivation Program of Chinese Academy of Sciences [RZ [2020]82]
- 100 Leading Talents of Guizhou Province
- Technology Plan Project of Guizhou Province [QKHPTRC[2019]5627]
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Three unprecedented nor-polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated from Hypericum sampsonii. Their structures were determined through various methods. Compound 1 showed significant inhibition of lipid accumulation in an oleic acid-treated HepG2 cell model.
Hypersampones A-C (1-3), three unprecedented nor-polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum sampsonii. These compounds represent the first nor-PPAPs with an unexpected tetracyclic 6/5/5/6 ring system. Their structures were assigned through the analysis of detailed spectroscopic data, X-ray crystallography, and electronic circular dichroism calculations. Compound 1 significantly inhibited the accumulation of lipid in an oleic acid-treated HepG2 cell model by suppressing the protein expression of FAS and ACACA at 5 mu M.
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