Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

A 68 mu g amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity.

Automated summary

The translation: A 68 mu g amount of an acyclic polyketide named beru'amide was isolated from a marine cyanobacterium Okeania sp. Several cutting-edge techniques were applied to determine the structure and perform the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide demonstrated strong antitrypanosomal activity.