Intraosseous rhabdomyosarcoma of the maxilla with TFCP2 fusion: A rare aggressive subtype with predilection for the gnathic bones

Article Pathology

Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022. Emerging Bone and Soft Tissue Neoplasms in the Head and Neck Region

Bin Xu

Summary: This review summarizes several emerging bone and soft tissue neoplasms of the head and neck region, discussing their clinical features, histologic characteristics, immunoprofile, and differential diagnoses. These tumors share similarities in morphology and immunopositivity, emphasizing the importance of careful consideration in the differential diagnosis.

HEAD & NECK PATHOLOGY (2022)

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Review Pathology

The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities

Joon Hyuk Choi et al.

Summary: Soft tissue tumors are rare and diagnostically challenging neoplasms that require accurate diagnosis for proper treatment and prognosis. The 5th Edition of the 2020 WHO classification of tumors of soft tissue and bone incorporates significant advances in molecular biology and diagnostic criteria, emphasizing the increasing reliance on molecular characteristics for tumor classification.

ADVANCES IN ANATOMIC PATHOLOGY (2021)

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Article Cell Biology

Head and neck rhabdomyosarcoma with TFCP2 fusions and ALK overexpression: a clinicopathological and molecular analysis of 11 cases

Bin Xu et al.

Summary: This study investigated the clinicopathological and molecular features of 11 head and neck RMSs, showing that these tumors have a distinctive spindle and epithelioid phenotype, peculiar immunoprofile, and are associated with poor prognosis.

HISTOPATHOLOGY (2021)

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Article Pathology

Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma

Carlos N. Prieto-Granada et al.

Summary: Spindle cell squamous cell carcinoma (SpC-SCC) is a rare type of head and neck cancer, predominantly affecting the oral cavity and larynx. Histologically, most tumors show a sarcoma-like pattern, with immunoreactivity for keratin and p40/p63 positive. Lymph node metastasis was observed in 31% of cases.

VIRCHOWS ARCHIV (2021)

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Article Dentistry, Oral Surgery & Medicine