Journal
JOURNAL OF DAIRY SCIENCE
Volume 99, Issue 6, Pages 4300-4302Publisher
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2015-10756
Keywords
N-acetylcysteine; bovine mastitis; pathogen; antibiotic susceptibility
Funding
- Chinese Central Government for Basic Scientific Research Operations in Commonwealth Research Institutes [1610322015007]
- Natural Science Foundation of Gansu Province, China [145RJYA311]
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The aim of this study was to investigate the effects of N-acetylcysteine (NAC) on antibiotic susceptibility of bovine mastitis pathogens including Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli, and Streptococcus agalactiae. Minimum inhibitory concentrations (MIC) were tested by the agar-based E-test method. The presence of 10 mM NAC reduced the MIC of penicillin and ampicillin but enhanced the MIC of erythromycin and ciprofloxacin for all of the strains. In addition, NAC-mediated modulation of MIC of kanamycin, tetracycline, and vancomycin was diverse, depending on the target bacterial pathogen and antibiotic being used. The results suggest that NAC is an important modulator of antibiotic activity against the major bovine mastitis pathogens.
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