Improving plant productivity by re-tuning the regeneration of RuBP in the Calvin-Benson-Bassham cycle

The Calvin-Benson-Bassham (CBB) cycle is arguably the most important pathway on earth, capturing CO2 from the atmosphere and converting it into organic molecules, providing the basis for life on our planet. This cycle has been intensively studied over the 50 yr since it was elucidated, and it is highly conserved across nature, from cyanobacteria to the largest of our land plants. Eight out of the 11 enzymes in this cycle catalyse the regeneration of ribulose-1-5 bisphosphate (RuBP), the CO2 acceptor molecule. The potential to manipulate RuBP regeneration to improve photosynthesis has been demonstrated in a number of plant species, and the development of new technologies, such as omics and synthetic biology provides exciting future opportunities to improve photosynthesis and increase crop yields.

Automated summary

The Calvin-Benson-Bassham (CBB) cycle is the most important pathway on earth, capturing and converting CO2 into organic molecules for the basis of life. This cycle has been extensively studied and is highly conserved in nature. The enzymes in this cycle regenerate the CO2 acceptor molecule RuBP. Manipulating RuBP regeneration has the potential to improve photosynthesis and increase crop yields.