Journal
NEW PHYTOLOGIST
Volume 235, Issue 4, Pages 1336-1343Publisher
WILEY
DOI: 10.1111/nph.18298
Keywords
Arabidopsis thaliana; chemical biology; chemical screening; circadian clock; small molecule; target identification
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Funding
- MEXT/JSPS KAKENHI [21H05656, 20H05411, 20K21272, 18H02136]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [21H05656, 20K21272, 18H02136, 20H05411] Funding Source: KAKEN
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Recent advances in chemical biology have revealed the function and regulation of plant circadian clocks through small molecules, including post-translational modifications and metabolites.
Circadian clocks regulate the diel rhythmic physiological activities of plants, enabling them to anticipate and adapt to day-night and seasonal changes. Genetic and biochemical approaches have suggested that transcription-translation feedback loops (TTFL) are crucial for Arabidopsis clock function. Recently, the study of chemical chronobiology has emerged as a discipline within the circadian clock field, with important and complementary discoveries from both plant and animal research. In this review, we introduce recent advances in chemical biology using small molecules to perturb plant circadian clock function through TTFL components. Studies using small molecule clock modulators have been instrumental for revealing the role of post-translational modification in the clock, or the metabolite-dependent clock input pathway, as well as for controlling clock-dependent flowering time.
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