4.6 Article

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Related references

Note: Only part of the references are listed.
Article Neurosciences

GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα

Mascia Amici et al.

Summary: Deregulation of GSK-3 beta is closely related to various serious brain conditions, and understanding its physiological functions in the central nervous system is crucial for disease research. Studies have shown that GSK-3 beta stabilizes synaptic NMDA receptors by phosphorylating PI4KII alpha, thereby controlling synaptic transmission.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

Substantial acetylcholine reduction in multiple brain regions of Mecp2-deficient female rats and associated behavioral abnormalities

Hiroyasu Murasawa et al.

Summary: This study assessed the effects of Mecp2 gene deletion on female rats and found that they exhibited phenotypes resembling RTT, providing a robust model for future research on RTT pathobiology and treatment.

PLOS ONE (2021)

Article Medicine, General & Internal

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia

Stephen K. Brannan et al.

Summary: The study showed that combined use of xanomeline and trospium in patients with schizophrenia led to a significant improvement in symptoms but was associated with cholinergic and anticholinergic adverse events, highlighting the need for larger and longer trials to determine efficacy and safety.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Biochemistry & Molecular Biology

The Molecular Basis of MeCP2 Function in the Brain

Rebekah Tillotson et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Article Clinical Neurology

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

Christopher S. Ward et al.

FRONTIERS IN NEUROLOGY (2020)

Review Pediatrics

Multisystem comorbidities in classic Rett syndrome: a scoping review

Cary Fu et al.

BMJ PAEDIATRICS OPEN (2020)

Editorial Material Pharmacology & Pharmacy

A Coordinated Attack: Rett Syndrome Therapeutic Development

Rocco G. Gogliotti et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Jerri M. Rook et al.

ACS CHEMICAL NEUROSCIENCE (2018)

Article Pharmacology & Pharmacy

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M-4 Muscarinic Receptor as a Novel Therapeutic Target

Rocco G. Gogliotti et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

Article Neurosciences

Structural and functional differences in the barrel cortex of Mecp2 null mice

Li-Jen Lee et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2017)

Article Neurosciences

Valley of death: A proposal to build a translational bridge for the next generation

Nao J. Gamo et al.

NEUROSCIENCE RESEARCH (2017)

Article Cell Biology

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Rocco G. Gogliotti et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Editorial Material Genetics & Heredity

MeCP2 mutations: progress towards understanding and treating Rett syndrome

Ruth R. Shah et al.

GENOME MEDICINE (2017)

Editorial Material Neurosciences

N-Methyl-D-Aspartate Receptors, Ketamine, and Rett Syndrome: Something Special on the Road to Treatments?

David M. Katz et al.

BIOLOGICAL PSYCHIATRY (2016)

Article Neurosciences

An optogenetic mouse model of rett syndrome targeting on catecholaminergic neurons

Shuang Zhang et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

Article Neurosciences

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Alexi Nott et al.

NATURE NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex

Keerthi Krishnan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Neurosciences

MeCP2 is required for activity-dependent refinement of olfactory circuits

Alicia L. Degano et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2014)

Article Neurosciences

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

Matthew J. Lyst et al.

NATURE NEUROSCIENCE (2013)

Article Biochemical Research Methods

Object recognition test in mice

Marianne Leger et al.

NATURE PROTOCOLS (2013)

Review Cell Biology

Preclinical research in Rett syndrome: setting the foundation for translational success

David M. Katz et al.

DISEASE MODELS & MECHANISMS (2012)

Review Clinical Neurology

Epilepsy in Rett syndrome, and CDKL5-and FOXG1-gene-related encephalopathies

Renzo Guerrini et al.

EPILEPSIA (2012)

Article Multidisciplinary Sciences

MeCP2, a key contributor to neurological disease, activates and represses transcription

Maria Chahrour et al.

SCIENCE (2008)

Review Pediatrics

Rett syndrome: clinical and molecular update

AK Percy et al.

CURRENT OPINION IN PEDIATRICS (2004)

Article Physiology

Pontine and basal forebrain cholinergic interaction: implications for sleep and breathing

CL Douglas et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2004)