4.6 Article

Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

NMDA and AMPA receptors dysregulation in Alzheimer's disease

Parvin Babaei

Summary: Alzheimer's disease is characterized by cognitive dysfunction and synaptic failure, with neurodegeneration negatively correlated with synaptic plasticity. Glutamatergic neurotransmission via NMDA and AMPA receptors is critical for synaptic plasticity, but excessive glutamate concentration can lead to excitotoxicity and neurodegeneration. Imbalances in NMDA and AMPA receptors can cause synaptopathy in AD.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Cell Biology

The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

Yew Mun Lee et al.

Summary: Cellular ROS can drive important biological signaling pathways through redox signaling, with mitochondria and mitochondrial H2O2 potentially implicated in the pathogenesis of neurodegenerative diseases.

CELL DEATH & DISEASE (2021)

Review Biochemistry & Molecular Biology

Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis

Roberta Cascella et al.

Summary: Alzheimer's disease is a common age-related neurodegenerative disorder characterized by amyloid beta-protein deposition and neurofibrillary tangles, leading to cognitive decline and dementia. Despite extensive research, the exact mechanisms underlying AD remain unknown and effective treatment is not available.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Neurosciences

Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer's Disease

Luisa Mueller et al.

Summary: Transgenic mouse models provide valuable insights into the pathogenesis of Alzheimer's disease and its impact on neuronal function, with implications for potential therapeutic interventions and the monitoring of amyloid-related neuronal dysfunction.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Neurosciences

Atrophy of lacunosum moleculare layer is important for learning and memory in APP/PS1 transgenic mice

Yi Zhang et al.

Summary: The changes in hippocampal microstructure in Alzheimer's disease model mice were found to be closely related to the decline in learning and memory abilities, characterized by a decrease in the numbers of neurons, dendritic spines, and mature oligodendrocytes, as well as smaller volumes in different layers.

NEUROREPORT (2021)

Article Biochemistry & Molecular Biology

PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation

Zeinab Y. Motawe et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

Article Chemistry, Medicinal

Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases

Na Ye et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Neurosciences

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

Sachchida Nand Rai et al.

NEUROTOXICITY RESEARCH (2019)

Article Multidisciplinary Sciences

Synapse loss and progress of Alzheimer's disease - A network model

G. Kashyap et al.

SCIENTIFIC REPORTS (2019)

Review Neurosciences

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

Daniel A. Ryskamp et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Neurosciences

Mutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability

Daniel A. Ryskamp et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Clinical Neurology

Alzheimer's disease

C. A. Lane et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

Review Neurosciences

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

Kavita Shah et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Cell Biology

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

Michael G. Erkkinen et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Review Cell Biology

Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease

Julia R. Wilkerson et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

Review Neurosciences

Role of Glutamate and NMDA Receptors in Alzheimer's Disease

Rui Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Behavioral Sciences

Dendritic spines: Morphological building blocks of memory

Menahem Segal

NEUROBIOLOGY OF LEARNING AND MEMORY (2017)

Review Neurosciences

Spine Dynamics: Are They All the Same?

Kalen P. Berry et al.

NEURON (2017)

Article Medicine, Research & Experimental

Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease

A. V. Bol'shakova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Article Biotechnology & Applied Microbiology

Astrocyte/neuron ratio and its importance on glutamate toxicity: an in vitro voltammetric study

Ahmet Hacimuftuoglu et al.

CYTOTECHNOLOGY (2016)

Article Neurosciences

Sex Dimorphism Profile of Alzheimer's Disease-Type Pathologies in an APP/PS1 Mouse Model

Shu-Sheng Jiao et al.

NEUROTOXICITY RESEARCH (2016)

Review Pathology

Dendritic Spine Pathology in Neurodegenerative Diseases

Jochen Herms et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Article Neurosciences

Mechanisms of tau and Aβ-induced excitotoxicity

Susanne P. Pallo et al.

BRAIN RESEARCH (2016)

Article Multidisciplinary Sciences

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors

Silvia Viana da Silva et al.

NATURE COMMUNICATIONS (2016)

Review Neurosciences

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

Keiichiro Minatohara et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Review Toxicology

Compromised MAPK signaling in human diseases: an update

Eun Kyung Kim et al.

ARCHIVES OF TOXICOLOGY (2015)

Article Multidisciplinary Sciences

Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid

Shang-Yi A. Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Neurosciences

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease

Carlos A. Saura et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Neurosciences

Amyloid-beta Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

Bernadette Schreiner et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Multidisciplinary Sciences

GSK3 beta Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons

German Cuesto et al.

PLOS ONE (2015)

Review Pharmacology & Pharmacy

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

Cassia R. Overk et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Review Neurosciences

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer's Disease

Tara L. Spires-Jones et al.

NEURON (2014)

Review Clinical Neurology

Dietary regulation of PI3K/AKT/GSK-3 beta pathway in Alzheimer's disease

Yasuko Kitagishi et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

Article Neurosciences

Learning improvement after PI3K activation correlates with de novo formation of functional small spines

Lilian Enriquez-Barreto et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Letter Biochemistry & Molecular Biology

The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor

K. Sahlholm et al.

MOLECULAR PSYCHIATRY (2013)

Review Neurosciences

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Pierre Paoletti et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Review Clinical Neurology

Synaptic plasticity in depression: Molecular, cellular and functional correlates

W. N. Marsden

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Review Clinical Neurology

A new player in the synaptopathy disease - Arc/Arg 3.1

Talitha L. Kerrigan et al.

FRONTIERS IN NEUROLOGY (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Editorial Material Cell Biology

PI3K-PKB/Akt Pathway

Brian A. Hemmings et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Review Biochemistry & Molecular Biology

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Michelle C. Mendoza et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Review Biochemistry & Molecular Biology

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Leslie Crews et al.

HUMAN MOLECULAR GENETICS (2010)

Article Neurosciences

Role of Oxidative Stress in the Progression of Alzheimer's Disease

Rukhsana Sultana et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Review Neurosciences

The synapsins: Key actors of synapse function and plasticity

F. Cesca et al.

PROGRESS IN NEUROBIOLOGY (2010)

Review Biochemistry & Molecular Biology

Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects

Jeremy P. E. Spencer et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Neurosciences

The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

Clive R. Bramham et al.

JOURNAL OF NEUROSCIENCE (2008)

Review Geriatrics & Gerontology

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

Stephen W. Scheff et al.

NEUROBIOLOGY OF AGING (2006)

Article Biochemistry & Molecular Biology

Spinophilin:: from partners to functions

D. Sarrouilhe et al.

BIOCHIMIE (2006)

Article Multidisciplinary Sciences

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

JS Jacobsen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size

SM Wojcik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Remodeling of synaptic actin induced by photoconductive stimulation

MA Colicos et al.

Article Multidisciplinary Sciences

Spinophilin regulates the formation and function of dendritic spines

J Feng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)