Journal
NEUROSCIENCE
Volume 500, Issue -, Pages 41-51Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2022.07.028
Keywords
Long non-coding RNA; H19; Cerebral ischemic stroke; Exosomes; Blood-brain barrier
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Funding
- National Natural Science Foundation of China [81771271, 81801171]
- 345 Talent Project of Shengjing Hospital [M0267]
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This study elucidates the relationship between the transport of lncRNA H19 by exosomes and blood-brain barrier breakdown induced by cerebral ischemic stroke.
Long non-coding RNA H19 (lncRNA H19) is transcribed from the H19 gene. We previously reported the role of lncRNA H19 in the pathogenesis of cerebral ischemic stroke. The present study aimed to elucidate the relationship between lncRNA H19 and blood-brain barrier breakdown induced by cerebral ischemic stroke. We observed that plasma levels of lncRNA H19 were positively associated with the extent of blood-brain barrier damage. In cellular co-culture models, neurons expressed and transported lncRNA H19 to astrocytes via exosomes and contributed to an increase in endothelium permeability induced by oxygen-glucose deprivation. Inhibition of neuronal exosomal lncRNA H19 regulated astrocytic microRNA (miR)-18a and vascular endothelial growth factor (VEGF) expression. Further, lncRNA H19 induced a decrease in tight junction proteins expression via the lncRNA H19/miR-18a/VEGF axis. This study highlights the transportation of lncRNA H19 by exosomes and the relationship between lncRNA H19 and blood-brain barrier breakdown. (C) 2022 Published by Elsevier Ltd on behalf of IBRO.
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