Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson's disease

NLRP3 is a central driver of neurodegeneration thought to function mainly in microglia. In this issue of Neuron, Panicker et al. (2022) find that NLRP3 is a parkin substrate that contributes significantly to Parkinson's disease pathogenesis by acting in neurons.

Automated summary

The study reveals that NLRP3, previously believed to mainly function in microglia, is also present in neurons and plays a significant role in the pathogenesis of Parkinson's disease.