Journal
NEURON
Volume 110, Issue 19, Pages 3064-3075Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2022.06.019
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Funding
- Israel Science Foundation (ISF) [1684/20]
- Howard Hughes Medical Institute at the Janelia Research Campus
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Sensory areas exhibit spontaneous activity in the absence of sensory stimuli, and recent studies have revealed high-dimensional patterns, correlation with behavior, and dissimilarity with sensory-driven activity. These findings suggest a new role for spontaneous activity in neural sensory computation.
Sensory areas are spontaneously active in the absence of sensory stimuli. This spontaneous activity has long been studied; however, its functional role remains largely unknown. Recent advances in technology, allowing large-scale neural recordings in the awake and behaving animal, have transformed our understanding of spontaneous activity. Studies using these recordings have discovered high-dimensional spontaneous activity patterns, correlation between spontaneous activity and behavior, and dissimilarity between spontaneous and sensory-driven activity patterns. These findings are supported by evidence from developing animals, where a transition toward these characteristics is observed as the circuit matures, as well as by evidence from mature animals across species. These newly revealed characteristics call for the formulation of a new role for spontaneous activity in neural sensory computation.
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