Journal
NEUROIMAGE
Volume 257, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119320
Keywords
Subthalamic nucleus; Functional connectivity; Parkinson?s disease; Deep brain stimulation; Magnetoencephalography
Funding
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [795866]
- Deutsche Forschungsgemeinschaft (DFG (German Research Foundation)) [424778381 - TRR 295, 410169619]
- BIH-Charite Clinician Scientist Program - Charite-Universitatsmedizin Berlin
- Berlin Institute of Health
- National Institutes of Health [2R01 MH113929]
- New Venture Fund (FFOR Seed Grant)
- DFG [KO5321/3, TR408/11]
- Wellcome [203147/Z/16/Z]
- JPND (Netherlands Organisation for Health Research and Development (ZonMw) -The Netherlands)
- JPND(Deutsches Zentrum fur Luft-und Raumfahrt-Germany)
- Marie Curie Actions (MSCA) [795866] Funding Source: Marie Curie Actions (MSCA)
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This study investigated the structural connectivity profile of the subthalamic nucleus (STN) using local field potential recordings and simultaneous magnetoencephalography. The results suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, with considerable spatial overlap between functional networks.
The subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by functional connectivity between local field potential recordings and simultaneous magnetoencephalography. Using a novel data set of 21 PD patients, we replicated previously reported cortico-STN coherence networks in the theta/alpha and beta frequency ranges, and looked for the spatial distribution of these networks within the STN region. Although theta/alpha and beta coherence peaks were both observed in on-medication recordings from electrode contacts at several locations within and around the STN, sites with theta/alpha coherence peaks were situated at significantly more inferior MNI coordinates than beta coherence peaks. Sites with only theta/alpha coherence peaks, i.e. without distinct beta coherence, were mostly located near the border of sensorimotor and cognitive/associative subregions as defined by a tractography-based atlas of the STN. Peak coherence values were largely unaltered by the medication state of the subject, however, theta/alpha peaks were more often identified in recordings obtained after administration of dopaminergic medication. Our findings suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, albeit with considerable spatial overlap between functional networks. Consequently, optimization of deep brain stimulation targeting might remain a trade-off between alleviating motor symptoms and avoiding adverse neuropsychiatric side effects.
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