Journal
NEUROCHEMICAL RESEARCH
Volume 47, Issue 9, Pages 2880-2889Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-022-03692-z
Keywords
Depression; Loureirin C; Xanthoceraside; Interleukin-17; Chronic unpredictable mild stress
Categories
Funding
- Japan Society for the Promotion of Science [17H04252, 20K07931, 20K16679]
- Private University Research Branding Project from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- Japan Science and Technology Agency (JST) FOREST Program [JPMJFR215H]
- Education and Research Facility of Animal Models for Human Diseases at Fujita Health University
- Smoking Research Foundation
- Takeda Science Foundation
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Loureirin C and Xanthoceraside can alleviate depression-like behaviors induced by chronic unpredicted mild stress (CUMS) and inhibit inflammation.
Major depressive disorder (MDD) is the most prevalent and serious psychiatric disease involving inflammation. Loureirin C and Xanthoceraside are extracts of dragon's blood and Xanthoceras sorbifolia Bunge, respectively, which have neuroprotective and anti-inflammatory properties. In this study, we examined whether Loureirin C and Xanthoceraside attenuated depression-like behaviors and inflammation induced by chronic unpredicted mild stress (CUMS) in mice. Adult C57BL/6 J mice exposed to CUMS for 4 weeks showed depression-like behaviors characterized by hyperactivity in a novel environment, decreased interaction time in the social interaction test, prolongation of eating latency in the novelty suppressed feeding test, and increased immobility in the forced swimming test. CUMS increased the expression of interleukin-17 (IL-17) in the prefrontal cortex (PFC). One week after exposure to CUMS, the mice were treated with Loureirin C (0.64 mg/kg) or Xanthoceraside (1.28 mg/kg) once a day for 3 weeks during CUMS. Loureirin C and Xanthoceraside significantly attenuated CUMS-induced behavioral impairment. Furthermore, both Loureirin C and Xanthoceraside prevented IL-17 expression induced by CUMS in the PFC. This data suggests that Loureirin C and Xanthoceraside have antidepressant-like properties that may be associated with the inhibition of IL-17 expression.
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