Journal
NEUROCHEMICAL RESEARCH
Volume 47, Issue 12, Pages 3697-3708Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-022-03714-w
Keywords
Astrocyte; Autophagy; Neurodegeneration; Cerebral ischemia; Depression
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Funding
- National Natural Science Foundation of China [82003727, 81872844]
- Zhejiang Provincial Natural Science Foundation [LQ21H310002]
- Opening Project of the Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University [2021E10014]
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Astrocytes contribute to maintaining cerebral homeostasis and have a significant role in various disorders through autophagy.
Astrocytes act as housekeeping cells for maintaining cerebral homeostasis and play an important role in many disorders. Recent studies further highlight the contribution of autophagy to astrocytic functions, including astrogenesis, the astrocytic removal of neurotoxins or stressors, and astrocytic polarization. More importantly, genetic and pharmacological approaches have provided evidence that outlines the contributions of astrocytic autophagy to several brain disorders, including neurodegeneration, cerebral ischemia, and depression. In this study, we summarize the emerging role of autophagy in regulating astrocytic functions and discuss the contributions of astrocytic autophagy to different CNS disorders.
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