☆ 4.6 Review

Cellular senescence: the good, the bad and the unknown

NATURE REVIEWS NEPHROLOGY (2022)

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Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

Agian Jeffilano Barinda et al.

NATURE COMMUNICATIONS (2020)

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BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake

Hui Wang et al.

AGING-US (2020)

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Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy

Norihiko Sasaki et al.

CELL COMMUNICATION AND SIGNALING (2020)

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

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M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice

Songyan Yu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence

Yue-Hua Jiang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Renal Programming by Transient Postnatal Overfeeding: The Role of Senescence Pathways

Christian Juvet et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

Kaj E. C. Blokland et al.

PHARMACEUTICS (2020)

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Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Julia Carracedo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

Sabena M. Conley et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Anuj K. Sharma et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype

Akshaya Chandrasekaran et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling

Fatouma Alimirah et al.

CANCER RESEARCH (2020)

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The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification

Estella Zuccolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos

Yuta Kawagoe et al.

AGING CELL (2020)

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Developmentally-programmed cellular senescence is conserved and widespread in zebrafish

Sabela Da Silva-Alvarez et al.

AGING-US (2020)

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Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor et al.

NATURE (2020)

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Cellular Senescence A New Player in Kidney Injury

Yongxin Li et al.

HYPERTENSION (2020)

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Article Medicine, Research & Experimental

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

Tao Liu et al.

LIFE SCIENCES (2020)

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Article Geriatrics & Gerontology

Emergence of T cell immunosenescence in diabetic chronic kidney disease

Yen-Ling Chiu et al.

IMMUNITY & AGEING (2020)

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Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease

Johannes Schroth et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence

Eunjin Bae et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways

Kazuyuki Okamura et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Seul Gi Kim et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2020)

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Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes

Minji Bang et al.

BIOMOLECULES & THERAPEUTICS (2019)

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Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2

Holly N. Wilkinson et al.

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Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells

Alessandro Bertolo et al.

SCIENTIFIC REPORTS (2019)

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c-Met as a new marker of cellular senescence

Maria Boichuck et al.

AGING-US (2019)

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An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2

Ara Cho et al.

MOLECULAR THERAPY (2019)

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Article Cell Biology

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury

Giuseppe Castellano et al.

AGING-US (2019)

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Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling

Chenchen Pi et al.

AGING-US (2019)

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Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Seo Rin Kim et al.

TRANSLATIONAL RESEARCH (2019)

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Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells

Marion Bourdens et al.

SCIENTIFIC REPORTS (2019)

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Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Adrian Santelli et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

Crystal A. Tonnessen-Murray et al.

JOURNAL OF CELL BIOLOGY (2019)

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Immunology of the ageing kidney

Yuki Sato et al.

NATURE REVIEWS NEPHROLOGY (2019)

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C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice

Liwen Zhang et al.

CELL DEATH & DISEASE (2019)

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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson et al.

EBIOMEDICINE (2019)

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Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

Olivier Malaise et al.

AGING-US (2019)

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The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells

Mai Shi et al.

CELLULAR SIGNALLING (2019)

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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

Satoru Yamagishi et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Metformin as Anti-Aging Therapy: Is It for Everyone?

Alexander A. Soukas et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

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Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence

Takahiro Sakai et al.

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Regulation of senescence and the SASP by the transcription factor C/EBPβ

Jacqueline Salotti et al.

EXPERIMENTAL GERONTOLOGY (2019)

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Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrPC-dependent enhancement of the mitochondrial function

Yong-Seok Han et al.

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Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment

Sandra Munoz-Galvan et al.

ONCOGENE (2019)

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NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling

Feilin Liu et al.

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Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma

Yasmin Kamal et al.

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Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy

Xiaohui Bian et al.

BMJ OPEN DIABETES RESEARCH & CARE (2019)

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Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Xiaolei Wang et al.

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c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors

Kevin C. Flanagan et al.

ONCOTARGET (2018)

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3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing

Luay Thanoon Younis et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence

Yangzi Song et al.

AGING CELL (2018)

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Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

Lucia Terlecki-Zaniewicz et al.

AGING-US (2018)

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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Athena Georgilis et al.

CANCER CELL (2018)

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Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype

Jingang Hou et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

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Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

Congwei Luo et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

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Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF-κB during Pseudomonas aeruginosa Infection

Hui Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Akiko Takahashi et al.

NATURE COMMUNICATIONS (2018)

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Reactive oxygen species and nitric oxide induce senescence of rudimentary leaves and the expression profiles of the related genes in Litchi chinensis

Haifang Yang et al.

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Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma

Xiuhua Xu et al.

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Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia

Patricia Sosa et al.

AGING AND DISEASE (2018)

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Biomarkers of Cellular Senescence and Skin Aging

Audrey S. Wang et al.

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Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh et al.

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Plasma and urinary p21: potential biomarkers of AKI and renal aging

Ali C. Johnson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Senescence promotes invivo reprogramming through p16INK4a and IL-6

Lluc Mosteiro et al.

AGING CELL (2018)

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The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Jerry M. Adams et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence

Siyuan Su et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

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States of G0 and the proliferation-quiescence decision in cells, tissues and during development

Dan Sun et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2017)

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Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells

Songtao Yu et al.

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Chronic Resveratrol Treatment Inhibits MRC5 Fibroblast SASP-Related Protumoral Effects on Melanoma Cells

Beatrice Menicacci et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)

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Identification of the activating cytotoxicity receptor NKG2D as a senescence marker in zero-hour kidney biopsies is indicative for clinical outcome

Julia Guenther et al.

KIDNEY INTERNATIONAL (2017)

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Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

Charles F. A. de Bourcy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Identification of HSP90 inhibitors as a novel class of senolytics

Heike Fuhrmann-Stroissnigg et al.

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Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via modulation of AMPK/mTOR signaling

Dan Dong et al.

ONCOTARGET (2017)

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Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

Camila Eleuterio Rodrigues et al.

STEM CELL RESEARCH & THERAPY (2017)

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Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells

Junhui Hu et al.

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Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo

Xiuzu Song et al.

REDOX BIOLOGY (2017)

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Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques

Maham Rais et al.

GEROSCIENCE (2017)

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Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

Juan Antonio Rodriguez et al.

NATURE ECOLOGY & EVOLUTION (2017)

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D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation

Akira Okada et al.

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Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice

Catherine Yzydorczyk et al.

SCIENTIFIC REPORTS (2017)

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Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production

Gemma Olmos et al.

AGING CELL (2017)

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Drug-Induced Kidney Injury in the Elderly

Sana Khan et al.

DRUGS & AGING (2017)

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p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Brandon M. Hall et al.

AGING-US (2017)

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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

Rong Wang et al.

AGING CELL (2017)

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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Marjolein P. Baar et al.

CELL (2017)

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Yi Zhu et al.

AGING-US (2017)

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Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

Dauren Alimbetov et al.

BIOGERONTOLOGY (2016)

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang et al.

NATURE MEDICINE (2016)

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Small molecule compounds that induce cellular senescence

Nadezhda V. Petrova et al.

AGING CELL (2016)

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Yi Zhu et al.

AGING CELL (2016)

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Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

Servet Ozcan et al.

AGING-US (2016)

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Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

Alexandra Bernadotte et al.

AGING-US (2016)

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Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans

Judith E. Carroll et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Editorial Material Biochemistry & Molecular Biology

Mitochondria and senescence: new actors for an old play

Nicolas Herranz et al.

EMBO JOURNAL (2016)

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Mitochondria are required for pro-ageing features of the senescent phenotype

Clara Correia-Melo et al.

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miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression

Shensheng Gu et al.

FEBS LETTERS (2016)

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Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation

Wensheng Yan et al.

GENES & DEVELOPMENT (2016)

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Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma

Qiao Zhang et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis

Yifan Chen et al.

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Challenges and opportunities for stem cell therapy in patients with chronic kidney disease

LaTonya J. Hickson et al.

KIDNEY INTERNATIONAL (2016)

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

Pierpaola Davalli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Knockdown of SIRT6 Enables Human Bone Marrow Mesenchymal Stem Cell Senescence

Xiao-Yan Zhai et al.

REJUVENATION RESEARCH (2016)

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Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

Myung Jin Son et al.

STEM CELLS (2016)

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Autophagy and Immune Senescence

Hanlin Zhang et al.

TRENDS IN MOLECULAR MEDICINE (2016)

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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Megan K. Ruhland et al.

NATURE COMMUNICATIONS (2016)

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ATF6α regulates morphological changes associated with senescence in human fibroblasts

Clementine Druelle et al.

ONCOTARGET (2016)

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Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

Jun Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

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Senescence from G2 arrest, revisited

Veronique Gire et al.

CELL CYCLE (2015)

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Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

Cheng-Feng Zhang et al.

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Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy

Huifang Cheng et al.

KIDNEY INTERNATIONAL (2015)

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Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation

Nuria Troyano et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2015)

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Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

Valentina Turinetto et al.

NUCLEIC ACIDS RESEARCH (2015)

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Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression

Nuria Troyano-Suarez et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells

Pei-Min Chen et al.

ONCOTARGET (2015)

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Bone Marrow Mesenchymal Stem Cell Transplantation Retards the Natural Senescence of Rat Hearts

Mingyu Zhang et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

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High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

Tzu-Ching Chang et al.

PLOS ONE (2015)

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Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Erli Zhang et al.

PLOS ONE (2015)

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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Raewyn C. Poulsen et al.

ANNALS OF THE RHEUMATIC DISEASES (2014)

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Rat Induced Pluripotent Stem Cells Protect H9C2 Cells from Cellular Senescence via a Paracrine Mechanism

Yuzhen Zhang et al.

CARDIOLOGY (2014)

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Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells

Armelle Corpet et al.

CHROMOSOMA (2014)

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Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

Francesca Rossiello et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)

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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Marco Demaria et al.

DEVELOPMENTAL CELL (2014)

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Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population

Mariavaleria Pellicano et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

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In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells

Birgit Berkenkamp et al.

PLOS ONE (2014)

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p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis

Elise Alspach et al.

CANCER DISCOVERY (2014)

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Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

David Vindrieux et al.

ONCOTARGET (2014)

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Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways

S. Rinaldi et al.

SCIENTIFIC REPORTS (2014)

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CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury

Derek P. DiRocco et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

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MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

Fabiola Olivieri et al.

AGE (2013)

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In senescence, age-associated B cells secrete TNF and inhibit survival of B-cell precursors*

Michelle Ratliff et al.

AGING CELL (2013)

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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation

Olga Moiseeva et al.

AGING CELL (2013)

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Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes

Milad S. Bitar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

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Article Biochemistry & Molecular Biology

Programmed Cell Senescence during Mammalian Embryonic Development

Daniel Munoz-Espin et al.

CELL (2013)

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Article Biochemistry & Molecular Biology

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

Mekayla Storer et al.

CELL (2013)

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Article Biochemistry & Molecular Biology

Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

Donald A. McCarthy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Immunology

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

Alexandre Iannello et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Urology & Nephrology

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling

Lili Zhou et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

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Article Biochemistry & Molecular Biology

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

H. Yasaei et al.

ONCOGENE (2013)

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Review Cell Biology

Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism

Charles T. Lutz et al.

AGING-US (2012)

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Article Oncology

Senescence as A Consequence of Ginsenoside Rg1 Response on K562 Human Leukemia Cell Line

Jun Liu et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)

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Article Oncology

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression

Ermira Pazolli et al.

CANCER RESEARCH (2012)

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Article Biochemistry & Molecular Biology

Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells

Ikuko Tsujimoto et al.

FEBS LETTERS (2012)

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Article Biochemistry & Molecular Biology

Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

Wei Gan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

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Article Cell Biology

Lamin B1 loss is a senescence-associated biomarker

Adam Freund et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

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Article Oncology

Inactivation of Heat Shock Factor Hsf4 Induces Cellular Senescence and Suppresses Tumorigenesis In Vivo

Xiongjie Jin et al.

MOLECULAR CANCER RESEARCH (2012)

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Article Multidisciplinary Sciences

Onset of Immune Senescence Defined by Unbiased Pyrosequencing of Human Immunoglobulin mRNA Repertoires

Florian Rubelt et al.

PLOS ONE (2012)

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Article Medical Laboratory Technology

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

Jun Liu et al.

TRANSLATIONAL RESEARCH (2012)

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Article Oncology

Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans

Antonio Bascones-Martinez et al.

ONCOLOGY LETTERS (2012)

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Review Cell Biology

Oxydative stress alters nuclear shape through lamins dysregulation A route to senescence

Aurelia Barascu et al.

NUCLEUS (2012)

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Review Physiology

The splicing factor SRSF1 as a marker for endothelial senescence

Francisco Javier Blanco et al.

FRONTIERS IN PHYSIOLOGY (2012)

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Article Physiology

INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury

David H. Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

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Article Geriatrics & Gerontology

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Flora Engelmann et al.

AGE (2011)

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Article Geriatrics & Gerontology

NKG2D expression in CD4+T lymphocytes as a marker of senescence in the aged immune system

Rebeca Alonso-Arias et al.

AGE (2011)

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Article Cell Biology

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

Javier A. Menendez et al.

AGING-US (2011)

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Article Hematology

Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence

Joonseok Cho et al.

BLOOD (2011)

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Article Developmental Biology

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

Hugh S. Gannon et al.

DEVELOPMENTAL BIOLOGY (2011)

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Article Peripheral Vascular Disease

Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State

Maki Uraoka et al.

HYPERTENSION (2011)

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Article Multidisciplinary Sciences

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Tae-Won Kang et al.

NATURE (2011)

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Article Cell Biology

Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age

Chloe Lescale et al.

AGING CELL (2010)

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Article Immunology

Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes

Stanley T. Parish et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2010)

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Article Medicine, Research & Experimental

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Andrea Alimonti et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

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Article Urology & Nephrology

Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury

Jens H. Westhoff et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

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Article Cell Biology

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Joon-Il Jun et al.

NATURE CELL BIOLOGY (2010)

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Article Cell Biology

Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells

Piotr Trzonkowski et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2010)

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Article Geriatrics & Gerontology

KLRG1-more than a marker for T cell senescence

Sian M. Henson et al.

AGE (2009)

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Article Biochemistry & Molecular Biology

Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence

Daniela Volonte et al.

EMBO REPORTS (2009)

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Article Cell Biology

TAp63 induces senescence and suppresses tumorigenesis in vivo

Xuecui Guo et al.

NATURE CELL BIOLOGY (2009)

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Article Biochemical Research Methods

Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo

Florence Debacq-Chainiaux et al.

NATURE PROTOCOLS (2009)

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Review Pharmacology & Pharmacy

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

David A. Gewirtz et al.

BIOCHEMICAL PHARMACOLOGY (2008)

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Article Biochemistry & Molecular Biology

S-Phase-specific activation of PKCα induces senescence in non-small cell lung cancer cells

Jose L. Oliva et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Developmental Biology

The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro

Laura A. Favetta et al.

BMC DEVELOPMENTAL BIOLOGY (2007)

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Article Oncology

Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells

Makoto Osanai et al.

CANCER SCIENCE (2007)

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Article Cell Biology

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis

Christopher J. Sarkisian et al.

NATURE CELL BIOLOGY (2007)

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Article Oncology

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

Dan Liu et al.

CANCER RESEARCH (2007)

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Article Oncology

Estrogens decrease γ-ray-induced senescence and maintain cell cycle progression in breast cancer cells independently of p53

Robert-Alain Toillon et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)

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Article Urology & Nephrology

Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease

B. Sis et al.

KIDNEY INTERNATIONAL (2007)

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Article Biochemistry & Molecular Biology

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice

Maria I. Rodriguez et al.

FREE RADICAL RESEARCH (2007)

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Article Multidisciplinary Sciences

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

Gong Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Oncology

Gadd45a suppresses ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence

Jennifer S. Tront et al.

CANCER RESEARCH (2006)

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Article Immunology

Modulation of canine immunosenescence by life-long caloric restriction

Elizabeth H. Greeley et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2006)

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Article Cell Biology

Upregulation of chicken p15INK4b at senescence and in the developing brain

Soo-Hyun Kim et al.

JOURNAL OF CELL SCIENCE (2006)

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Article Multidisciplinary Sciences

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

J Bartkova et al.

NATURE (2005)

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Article Cell Biology

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells

DJ Kurz et al.

JOURNAL OF CELL SCIENCE (2004)

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Article Oncology

Nuclear accumulation of globular actin as a cellular senescence marker

IH Kwak et al.

CANCER RESEARCH (2004)

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Article Pharmacology & Pharmacy

Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice

T Yokozawa et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2004)

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Article Pathology

The role of replicative senescence in chronic allograft nephropathy

S Ferlicot et al.

HUMAN PATHOLOGY (2003)

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Article Biochemistry & Molecular Biology

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts

V Dulic et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

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Article Oncology

Is β-galactosidase staining a marker of senescence in vitro and in vivo?

J Severino et al.

EXPERIMENTAL CELL RESEARCH (2000)

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