Journal
NATURE GENETICS
Volume 54, Issue 6, Pages 746-747Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-022-01096-x
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A new study used CRISPR-Cas9-based base editing to simultaneously mutate all copies of histone H3 genes in mammals, revealing the functional importance of H3K27me3 in Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation.
A new study employs CRISPR-Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation.
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