Voyage to minimal base editors

Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

Automated summary

A TnpB-based adenine base editor has been developed and can be loaded into a single AAV vector without compromising editing activity, showing potential for efficient gene editing.