Journal
NATURE CELL BIOLOGY
Volume 24, Issue 8, Pages 1189-1191Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-022-00967-z
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EGFR plays a tumour-suppressive role in EGFR-amplified glioblastoma, regulated by ligand abundance. Increased EGFR ligand suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.
EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.
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