Journal
NATURE BIOTECHNOLOGY
Volume 40, Issue 9, Pages 1341-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41587-022-01367-2
Keywords
-
Categories
Funding
- Second Tibetan Plateau Scientific Expedition and Research Program (STEP) [2019QZKK0503, 2021QZKK0100]
- National Key Research and Development Plans [2019YFC1509103, 2021YFC2300904]
- Major Research Plan of the National Natural Science Foundation of China [91851207]
Ask authors/readers for more resources
The study presents a comprehensive glacier microbial genome and gene catalog from Tibetan glaciers, which includes genomes and metagenome-assembled genomes representing 968 candidate species from 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes and has demonstrated its utility in exploring secondary metabolite biosynthetic potentials, identifying virulence factors, and comparing global glacier metagenomes.
Glaciers represent a unique inventory of microbial genetic diversity and a record of evolution. The Tibetan Plateau contains the largest area of low-latitude glaciers and is particularly vulnerable to global warming. By sequencing 85 metagenomes and 883 cultured isolates from 21 Tibetan glaciers covering snow, ice and cryoconite habitats, we present a specialized glacier microbial genome and gene catalog to archive glacial genomic and functional diversity. This comprehensive Tibetan Glacier Genome and Gene (TG2G) catalog includes 883 genomes and 2,358 metagenome-assembled genomes, which represent 968 candidate species spanning 30 phyla. The catalog also contains over 25 million non-redundant protein-encoding genes, the utility of which is demonstrated by the exploration of secondary metabolite biosynthetic potentials, virulence factor identification and global glacier metagenome comparison. The TG2G catalog is a valuable resource that enables enhanced understanding of the structure and functions of Tibetan glacial microbiomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available