Long-sought mediator of vitamin K recycling

Article Multidisciplinary Sciences

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Eikan Mishima et al.

Summary: A study identifies the anti-ferroptotic function of vitamin K and reveals FSP1 as the enzyme mediating warfarin-resistant vitamin K reduction, highlighting the importance of FSP1 in protecting cells against lipid peroxidation and ferroptosis.

NATURE (2022)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Genetics & Heredity

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

Alison R. Barton et al.

Summary: This study leveraged haplotype sharing in the UK Biobank to impute exome-wide variants and identified significant associations involving rare protein-altering variants. The research revealed significant associations in multiple genes and proposed allelic series containing multiple "likely-causal" variants.

NATURE GENETICS (2021)

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Article Multidisciplinary Sciences