Journal
NATURE
Volume 607, Issue 7920, Pages 747-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41586-022-04909-5
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Categories
Funding
- DFG [MU 4116/1-1]
- Portuguese Foundation for Science and Technology (FCT) [PD/BD/114273/2016]
- la Caixa Banking Foundation [LCF/PR/HR17/52150002]
- FCT-FundacAo para a Ciencia e Tecnologia, I.P.
- European Regional Development Fund (ERDF) [02/SAICT/300081/2017]
- research infrastructure Congento
- Lisboa Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
- FCT-FundacAo para a Ciencia e Tecnologia (Portugal) [LISBOA-01-0145-FEDER-022170]
- FundacAo Champalimaud
- Fundação para a Ciência e a Tecnologia [PD/BD/114273/2016] Funding Source: FCT
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When animals decide what to eat, they consider sensory information and internal states. This study found that metabolic state globally modulates sensorimotor processing, while reproductive state locally regulates how sensory information is transformed into feeding motor output. These two states synergistically regulate food intake and choice.
When deciding what to eat, animals evaluate sensory information about food quality alongside multiple ongoing internal states(1-10). How internal states interact to alter sensorimotor processing and shape decisions such as food choice remains poorly understood. Here we use pan-neuronal volumetric activity imaging in the brain of Drosophilamelanogaster to investigate the neuronal basis of internal state-dependent nutrient appetites. We created a functional atlas of the ventral fly brain and find that metabolic state shapes sensorimotor processing across large sections of the neuropil. By contrast, reproductive state acts locally to define how sensory information is translated into feeding motor output. These two states thus synergistically modulate protein-specific food intake and food choice. Finally, using a novel computational strategy, we identify driver lines that label neurons innervating state-modulated brain regions and show that the newly identified 'borboleta' region is sufficient to direct food choice towards protein-rich food. We thus identify a generalizable principle by which distinct internal states are integrated to shape decision making and propose a strategy to uncover and functionally validate how internal states shape behaviour.
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