Journal
NATURAL PRODUCT RESEARCH
Volume 37, Issue 20, Pages 3512-3518Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2089671
Keywords
Deep-sea fungus; Purpureocillium sp; furanone analog; antioxidant; pancreatic lipase
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A new furanone analog and six known compounds were isolated from a deep-sea fungus. One of the compounds exhibited modest antioxidant activity while others showed pancreatic lipase inhibitory activities.
A new furanone analog, (E)-2-(8,9-dihydroxy-6,8-dimethyldec-4-en-2-yl)-met-hylfuran-3(2H)-one (1), together with six known compounds, including two diterpenoids (2 and 3), one butyrolactone (4) and three isocoumarins (5-7), were isolated from a deep-sea fungus, Purpureocillium sp. SCSIO 06693. Among them, compound 1 existed as two tautomeric forms (1a and 1b) differing in configuration of the furan ring. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Isolated compounds were evaluated for their cytotoxic, antiviral, antibacterial, antioxidant, acetyl cholinesterase (AChE) and pancreatic lipase (PL) enzyme inhibitory activities. Biological evaluation results revealed that compound 4 showed modest antioxidant activity against DPPH with IC50 value of 72.03 mu M. In addition, compounds 1-4 exhibited PL enzyme inhibitory activities.
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