Journal
NATURAL PRODUCT RESEARCH
Volume 37, Issue 5, Pages 809-818Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2089668
Keywords
Ravenala madagascariensis; antihypertensive virtue; androsta-1; 4-dien-3; 16-dione; vaso-relaxing activity
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Androsta-1,4-dien-3,16-dione was isolated from the ethanolic extract of Ravenala madagascariensis for the first time. It exhibited the strongest vasorelaxant effect, possibly due to the non-specific inhibition of calcium influx.
Androsta-1,4-dien-3,16-dione was isolated for the first time from the plant kingdom of the ethanolic extract of the Ravenala madagascariensis' inflorescence by the bio-guided method. Its structure was elucidated by NMR and MS spectroscopic data analysis. The vascular effects of ethanol extracts, fractions and androsta-1,4-dien-3,16-dione were assessed on the phenylephrine pre-contracted isolated rat aorta. The isolated compound exerted the most potent vaso-relaxing effect (EC50 = 109.32 +/- 15.82 mu M) than the ethanol extract and fractions. The pharmacological mechanism of its vaso-relaxing action was analysed on isolated rat aorta using free-endothelial vascular tissue, specific contracting reagents (CaCl2 and KCl), antagonist (propranolol), enzyme inhibitors (L-NAME, methylene blue) and channel blocker (glibenclamide). Its vaso-relaxing activity could be due, at least partly, to the non-specific inhibition of the calcic influx.
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