Journal
NATURAL PRODUCT RESEARCH
Volume 37, Issue 5, Pages 798-802Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2089138
Keywords
Acute liver failure; myricetin; inflammation; oxidative stress; signaling
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This study demonstrates that myricetin has protective effects against acute liver failure induced by lipopolysaccharide/D-galactosamine. Myricetin can reduce pathological changes, improve liver function, alleviate oxidative stress and inflammation. These protective effects may be mediated by regulating the Nrf2 signaling pathway.
This study aimed to investigate the protective effects and mechanisms of myricetin on acute liver failure in mice induced by lipopolysaccharide (LPS)/D-galactosamine (D-Gal). Our results showed myricetin (25, 50 and 100 mg/kg) pretreatment significantly improved the pathological changes of liver tissues, decreased serum ALT and AST (p < 0.001) induced by LPS/D-GalN. Moreover, MDA and MPO levels were reduced (p < 0.001), CAT and SOD activities were increased (p < 0.001) with myricetin (50 and 100 mg/kg) pretreatment. Likewise, inflammatory cytokines TNF-alpha and IL-6 mRNA in liver tissues were markedly decreased (p < 0.001) by myricetin. Besides, Nrf2 protein expression was drastically elevated (p < 0.001) by myricetin (25, 50 and 100 mg/kg). All these findings imply that myricetin may protect against acute liver failure by suppressing inflammation and regulating oxidative stress via Nrf2 signaling, and that it may be a possible strategy to avoid liver damage.
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