Two new chlorinated sesquiterpenes from Sigesbeckia orientalis

Article Chemistry, Applied

New sesquiterpene and flavone arabinofuranoside derivative from the leaves of Fissistigma bicolor

Pham Thi Tham et al.

Summary: A new compound and six known compounds were isolated from the leaves of Fissistigma bicolor. Their chemical structures were determined and two compounds showed potential inhibition of NO production.

NATURAL PRODUCT RESEARCH (2023)

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Article Chemistry, Applied

Sigesbeckia K and L, two new diterpenoids from Sigesbeckia glabrescens with anti-inflammatory activity

GaoSheng Hu et al.

Summary: A chemical investigation of Sigesbeckia glabrescens Makino identified four compounds, including two previously undescribed compounds Sigesbeckia K (1) and Sigesbeckia L (2). The anti-inflammatory effects of these compounds showed potential inhibitory effects.

NATURAL PRODUCT RESEARCH (2022)

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Article Chemistry, Applied

Isolation and characterization of ent-pimarane diterpenoids from Sigesbeckia pubescens

Jianbin Wang et al.

Summary: Five new ent-pimarane diterpenoids were isolated from the ethanol extract of Sigesbeckia pubescens, with compound 4 showing significantly inhibitory activity on NO production in macrophage cells, with an IC50 value of 5.9 μM.

NATURAL PRODUCT RESEARCH (2021)

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Review Plant Sciences

Botany, traditional use, phytochemistry, pharmacology and toxicology of Sigesbeckiae Herba (Xixiancao): a review

Hong Xun Tao et al.

Summary: Sigesbeckiae Herba is a traditional Chinese herbal medicine with a long history of use for inflammatory diseases. Scientific research has shown that it contains a wide variety of bioactive compounds, with pharmacological activities such as anti-inflammatory, immunomodulatory, and anti-cancer effects. Although no significant side effects have been reported in clinics, potential pulmonary toxicity from water extracts has been observed in experimental animals. Further research is recommended to explore the molecular mechanisms of its pharmacological activities and potential toxicities.

PHYTOCHEMISTRY REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Diverse diterpenoids and sesquiterpenoids from Siegesbeckia pubescens and their activity against RANKL-induced osteoclastogenesis

Zhejun Sun et al.

Summary: Phytochemical investigation of Siegsebeckiapubescens revealed the presence of various diterpenoids and sesquiterpenoids, including new compounds. Several sesquiterpenoids showed potent inhibition of osteoclastogenesis, indicating the potential of S. pubescens as a source for antiosteoporosis agents.

BIOORGANIC CHEMISTRY (2021)

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Article Chemistry, Medicinal

Six novel lignanoids with complex structures from Sigesbeckia glabrescens Makino with their cytotoxic activities

Xiao-Xu Gao et al.

Summary: In this study, ten lignanoids were isolated from the aerial parts of Sigesbeckia glabrescens Makino, including six new compounds. Among them, new compounds 2 and 5 exhibited significant cytotoxicity against human lung adenocarcinoma cells.

FITOTERAPIA (2021)

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Article Plant Sciences

Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β

Xiaoxu Gao et al.

Summary: Chromatographic fractionation of Sigesbeckia glabrescens led to the identification of 10 new sesquiterpene lactones, with siegesbeckialide I showing the most potent anti-inflammatory activity by inhibiting the release of multiple inflammatory mediators. This compound directly binds to inhibitors of IKK alpha/beta, leading to the downregulation of NF-kappa B signaling pathway.

JOURNAL OF NATURAL PRODUCTS (2021)

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Article Biochemistry & Molecular Biology

Guaianolide sesquiterpenes and benzoate esters from the aerial parts of Siegesbeckia orientalis L. and their xanthine oxidase inhibitory activity

Dan Thi Thuy Hang et al.

Summary: In this study, twelve compounds were isolated from S. orientalis, with two benzyl benzoate derivatives showing the best xanthine oxidase inhibitory activity. Molecular docking studies also indicated favorable binding energies for all isolated compounds with xanthine oxidase, outperforming the positive control allopurinol.

PHYTOCHEMISTRY (2021)

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Review Plant Sciences

Herba Siegesbeckiae: A review on its traditional uses, chemical constituents, pharmacological activities and clinical studies

Qi Wang et al.

Summary: Herba Siegesbeckiae, also known as Xi-Xian Cao in Chinese, has been traditionally used for treating rheumatic arthralgia in China since the Tang dynasty. Studies have shown that it contains various chemical constituents and exhibits multiple pharmacological activities, including anti-inflammatory, anticancer, antiallergic, and antioxidant effects. Further research on toxicity and quality control is needed for future evaluation of its efficacy and safety.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences