4.6 Article

Yolk-shell shaped Au-Bi2S3 heterostructure nanoparticles for controlled drug release and combined tumor therapy

Journal

NANOTECHNOLOGY
Volume 33, Issue 45, Pages -

Publisher

IOP Publishing Ltd
DOI: 10.1088/1361-6528/ac85c2

Keywords

bismuth sulfide nanomaterials; drug delivery; synergistic therapy; phase change materials

Funding

  1. National Natural Science Foundation of China [81901868, 82072098]
  2. Fundamental Research Funds for the Central Universities [2572022BU04]

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In this study, Au-Bi2S3 nanomaterial was prepared with excellent photothermal conversion efficiency and free radicals yield. The drug delivery capacity was confirmed by co-loading drugs, and the nanoplatform showed cell selectivity and enhanced cancer cell inhibition ability. The results highlight the potential of this nanoplatform for controlled drug release and synergistic cancer therapy.
To fabricate a novel stimuli-responsive system enabling controlled drug release and synergistic therapy, yolk-shell shaped bismuth sulfide modified with Au nanoparticles (Au-Bi2S3) was prepared. The Au-Bi2S3 nanomaterial with heterojunction structure exhibited excellent photothermal conversion efficiency and considerable free radicals yield under laser irradiation. The drug delivery capacity was confirmed by co-loading Berberine hydrochloride (BBR) and a phase change material 1-tetradecanol (PCM), which could be responsible for NIR light induced thermal controlled drug release. In vitro investigation demonstrated that Au-Bi2S3 has cell selectivity, and with the assistance of the properties of Au-Bi2S3, the loaded drug could give full play to their cancer cell inhibition ability. Our work highlights the great potential of this nanoplatform which could deliver and control Berberine hydrochloride release as well as realize the synergistic anti-tumor strategy of photothermal therapy, photodynamic therapy and chemotherapy for tumor therapy.

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