Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 43, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.nano.2022.102554
Keywords
Glioblastoma; Temozolomide; Temperature-sensitive liposomes; Pyroptosis
Funding
- National Natural Science Foundation of China [81600159]
- Natural Science Foundation of Jiangsu Province [BK20131015]
- Six Talents Peak High-Level Talents Project of Jiangsu Province [2016-WSN-080]
- 333 High-Level Talent Training Project of Jingsu Province [LGY2016019]
- Science and Education Invigorate Health Project of Jingsu Province [QNRC2016677]
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In this study, a controllable drug carrier, TMZ/Fe-TSL, was developed and shown to induce GBM cell death and promote ROS production when exposed to AMF. The way and mechanisms of cell death may involve ROS and pyroptosis.
Glioblastoma (GBM) is the most fatal and common type of primary malignant tumors in central nervous system. Chemotherapy drugs are difficult to reach the encephalic region effectively due to blood-brain barrier (BBB), but functional nanoparticle drug carriers can help to solve the problem. Herein, we developed a controllable drug carrier called temozolomide magnetic temperature-sensitive liposomes (TMZ/Fe-TSL) to investigate its feasibility and molecular mechanisms on GBM. Our research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cell death and promote the production of ROS. It also showed that the expression of NLRP3, CASP1 and N-GSDMD was upregulated compared to the control group, while the expression of CASP3 showed a reverse change. The results indicated that TMZ/Fe-TSL exposed to the AMF was capable of inducing GBM cells death. And the way and mechanisms of cell death may involve in ROS and pyroptosis, but not apoptosis. (c) 2022 The Authors. Published by Elsevier Inc.
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