Journal
NANO LETTERS
Volume 22, Issue 14, Pages 5916-5921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.2c01932
Keywords
Metamaterials; Hyperbolic metamaterials; Super-resolution microscopy; Structured illumination microscopy; Metamaterial assisted illumination; Nanoscopy
Categories
Funding
- Gordon and Betty Moore Foundation
- NRF Grant [2014M3A6B3063708, 2021R1F1A1062916]
- National Research Foundation of Korea [2014M3A6B3063708] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Researchers have fabricated high-quality ultrathin layered hyperbolic metamaterials (HMMs) for the use in super-resolution microscopy. By using this ultrathin layered HMM-assisted illumination, they achieved a 14-fold improvement in imaging resolution, which was verified through experiments.
Metamaterial-assisted illumination nanoscopy (MAIN) has been proven to be a promising approach for super-resolution microscopy with up to a 7-fold improvement in imaging resolution. Further resolution enhancement is possible in principle, however, has not yet been demonstrated due to the lack of high-quality ultrathin layered hyperbolic metamaterials (HMMs) used in the MAIN. Here, we fabricate a low-loss composite HMM consisting of high-quality bilayers of Al-doped Ag and MgO with a nominal thickness of 2.5 nm, and then use it to demonstrate an ultrathin layered hyperbolic metamaterial-assisted illumination nanoscopy (ULH-MAIN) with a 14-fold imaging resolution improvement. This improvement of resolution is achieved in fluorescent beads super-resolution experiments and verified with scanning electron microscopy. The ULH-MAIN presents a simple super-resolution imaging approach that offers distinct benefits such as low illumination power, low cost, and a broad spectrum of selectable probes, making it ideal for dynamic imaging of life science samples.
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