Differential vulnerability of thalamic nuclei in multiple sclerosis

Article Radiology, Nuclear Medicine & Medical Imaging

Thalamic Nuclei Volumes and Their Relationships to Neuroperformance in Multiple Sclerosis: A Cross-Sectional StructuralMRIStudy

Niels Bergsland et al.

Summary: The study found that compared to healthy controls, multiple sclerosis patients had smaller thalamic nuclei volumes and worse neuroperformance assessments. The various thalamic nuclei showed different levels of correlation with clinical disability, and assessing individual thalamic nuclei volumes can help understand the relationship between thalamic pathology and MS-related disability.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2021)

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Article Clinical Neurology

In vivo gradients of thalamic damage in paediatric multiple sclerosis: a window into pathology

Ermelinda De Meo et al.

Summary: In pediatric multiple sclerosis patients, the thalamus undergoes various pathological changes including focal lesions, microstructural damage, and atrophy. Utilizing multiparametric magnetic resonance imaging allows for the detection of these changes in relation to the distance from the thalamus to the CSF and white matter.

BRAIN (2021)

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Article Clinical Neurology

Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement

Daniel Ontaneda et al.

Summary: Multiple sclerosis is not only a white matter disease, but also involves grey matter injury, especially in deep grey matter regions. The deep grey matter is uniquely suited for studying the mechanisms and clinical relevance of tissue injury in multiple sclerosis using magnetic resonance techniques. MRI characterization of deep grey matter properties has potential as clinical trial end points for neurodegenerative aspects of multiple sclerosis.

BRAIN (2021)

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Article Clinical Neurology

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Matteo Pardini et al.

Summary: While multiple sclerosis can affect any part of the CNS, it does not do so evenly. Lesions tend to occur around the ventricles in white matter, and mainly in the outermost cortex in grey matter. Neuronal loss is greater in the outermost layers of cortical grey matter, with the most severe abnormalities near the ventricular surface. The cause of these gradients remains uncertain, but factors released from meningeal inflammation into the CSF may play a role.

BRAIN (2021)

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Article Neurosciences