Journal
MOLECULES
Volume 27, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/molecules27144529
Keywords
metal-organic frameworks; enzymatic immobilization; enzymes; enzymatic catalysis; industrial application
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [311062/2019-9]
- Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP) [PS1-00186-00216.01.00/21]
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Enzymatic biocatalysis is a sustainable technology that relies on versatile and efficient enzymes. However, the biological activity of enzymes can be affected by external conditions and chemical compounds. Metal-organic frameworks (MOFs) have emerged as effective supports for enzyme immobilization to protect enzymes from environmental influences.
Enzymatic biocatalysis is a sustainable technology. Enzymes are versatile and highly efficient biocatalysts, and have been widely employed due to their biodegradable nature. However, because the three-dimensional structure of these enzymes is predominantly maintained by weaker non-covalent interactions, external conditions, such as temperature and pH variations, as well as the presence of chemical compounds, can modify or even neutralize their biological activity. The enablement of this category of processes is the result of the several advances in the areas of molecular biology and biotechnology achieved over the past two decades. In this scenario, metal-organic frameworks (MOFs) are highlighted as efficient supports for enzyme immobilization. They can be used to 'house' a specific enzyme, providing it with protection from environmental influences. This review discusses MOFs as structures; emphasizes their synthesis strategies, properties, and applications; explores the existing methods of using immobilization processes of various enzymes; and lists their possible chemical modifications and combinations with other compounds to formulate the ideal supports for a given application.
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