Journal
MOLECULES
Volume 27, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/molecules27113595
Keywords
GABAergic system; seizures; epilepsy; plant oils; endocannabinoids
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [434501/2018-2]
- Fundacao de Amparo a Pesquisa do Estado do Para (FAPESPA) [063/2020]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Pro-Reitoria de Pesquisa e Pos-graduacao (PROPESP-UFPA)
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Seizures and epilepsy are common neurological disorders that require research into new treatment options. Studies have shown that endocannabinoids can modulate the balance between excitatory and inhibitory neurotransmitters. Plant oils from the Amazon region are a valuable source for synthesizing compounds similar to endocannabinoids, which can be used for developing new anticonvulsant therapies.
Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies.
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