Journal
MOLECULES
Volume 27, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules27134101
Keywords
anti-allergic effect; degranulation; Cuminum cyminum L; umbelliferose
Funding
- SB Foods Inc.
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This study identified umbelliferose as the active compound in cumin seeds that suppresses degranulation. Umbelliferose was found to significantly inhibit antigen-induced degranulation. Additionally, raffinose was also found to have similar effects, although less potent.
Cuminum cyminum L. (cumin) is an annual plant of the Umbelliferae family native to Egypt. We previously showed that the aqueous extract of cumin seeds suppresses degranulation by downregulating the activation of antigen-induced intracellular signaling molecules in rat basophilic leukemia RBL-2H3 cells. However, the active substances in the extract have not yet been identified. Accordingly, herein, we aimed to ascertain the water-soluble substances present in cumin seeds that inhibit degranulation, which led to the identification of umbelliferose, a characteristic trisaccharide present in plants of the Umbelliferae family. Our study is the first to reveal the degranulation-suppressing activity of umbelliferose, and quantification studies suggest that cumin seed powder contains 1.6% umbelliferose. Raffinose, an isomer of umbelliferose, was also found to significantly suppress antigen-induced degranulation, but less so than umbelliferose. Both umbelliferose and raffinose contain sucrose subunits in their structures, with galactose moieties bound at different sites. These differences in structure suggest that the binding of galactose to the sucrose subunit at the alpha 1-2 bond contributes to its strong degranulation-inhibiting properties.
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