Synthesis, Crystal Structures, Lipophilic Properties and Antimicrobial Activity of 5-Pyridylmethylidene-3-rhodanine-carboxyalkyl Acids Derivatives

The constant increase in the resistance of pathogenic bacteria to the commonly used drugs so far makes it necessary to search for new substances with antibacterial activity. Taking up this challenge, we obtained a series of rhodanine-3-carboxyalkyl acid derivatives containing 2- or 3- or 4-pyridinyl moiety at the C-5 position. These compounds were tested for their antibacterial and antifungal activities. They showed activity against Gram-positive bacteria while they were inactive against Gram-negative bacteria and yeast. In order to explain the relationship between the activity of the compounds and their structure, for selected derivatives crystal structures were determined using the X-ray diffraction method. Modeling of the isosurface of electron density was also performed. For all tested compounds their lipophilicity was determined by the RP-TLC method and by calculation methods. On the basis of the carried-out research, it was found that the derivatives with 1.5 N center dot center dot center dot S electrostatics interactions between the nitrogen atom in the pyridine moiety and the sulfur atom in the rhodanine system showed the highest biological activity.

Automated summary

The constant increase in resistance of pathogenic bacteria to commonly used drugs necessitates the search for new antibacterial substances. In this study, a series of rhodanine-3-carboxyalkyl acid derivatives containing pyridinyl moiety were obtained and tested for their antibacterial and antifungal activities. The results showed activity against Gram-positive bacteria while they were inactive against Gram-negative bacteria and yeast. Crystal structures and lipophilicity analysis revealed that derivatives with 1.5 NS electrostatic interactions exhibited the highest biological activity.