Journal
MOLECULES
Volume 27, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules27134112
Keywords
microwave irradiation; Novozym 435; cytidine; monomer; smart materials
Funding
- Fraunhofer Internal Programs [Discover 840 205]
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The optimization of lipase-catalyzed synthesis of the monomer 5'-O-methacryloylcytidine with the assistance of microwave irradiation was described. Variable reaction parameters were investigated to find the optimum conditions for obtaining the highest yield.
Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5 ' position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5 '-O-methacryloylcytidine with the assistance of microwave irradiation. Variable reaction parameters, such as enzyme concentration, molar ratio of the substrate, reaction temperature and reaction time, were investigated to find the optimum reaction condition in terms of obtaining the highest yield.
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