Journal
MOLECULES
Volume 27, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/molecules27154836
Keywords
specialized pro-resolving mediators; resolvins; maresins; annexins; lipoxins; protectins; glial cells; neuroinflammation; neurodegeneration; cerebrovascular disorders; multiple sclerosis; dementia
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This article highlights the significance of specialized pro-resolving mediators (SPMs) in the inflammation environment and their role in neuroinflammation and major neurological diseases.
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases.
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