4.7 Article

The antiviral drug telaprevir induces cell death by reducing FOXA1 expression in estrogen receptor α (ERα)-positive breast cancer cells

Related references

Note: Only part of the references are listed.
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

A New Anti-Estrogen Discovery Platform Identifies FDA-Approved Imidazole Anti-Fungal Drugs as Bioactive Compounds against ERα Expressing Breast Cancer Cells

Manuela Cipolletti et al.

Summary: 17 beta-estradiol acts through estrogen receptor alpha to regulate cell proliferation and sustain the progression of ER alpha positive breast cancers. Using an anti-estrogen discovery platform, new FDA-approved drugs like clotrimazole and fenticonazole have been identified to inhibit E2:ER alpha signaling, preventing ER alpha transcriptional signaling and proliferation in primary and metastatic BC cells. These drugs also show anti-proliferative effects in 3D cancer models and synergize with CDK4/CDK6 inhibitors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Real-time measurement of E2: ERα transcriptional activity in living cells

Manuela Cipolletti et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Unexpected Impact of a Hepatitis C Virus Inhibitor on 17β-Estradiol Signaling in Breast Cancer

Stefania Bartoloni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Breast Cancer Treatment A Review

Adrienne G. Waks et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Cell Biology

Strategies to degrade estrogen receptor α in primary and ESR1 mutant-expressing metastatic breast cancer

Claudia Busonero et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer

Xiaoyong Fu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

A high throughput method to study the physiology of E2:ER signaling in breast cancer cells

Stefano Leone et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Dominant Role of Forkhead Box Proteins in Cancer

Duc-Hiep Bach et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Chemistry, Multidisciplinary

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Dan Wang et al.

ACTA PHARMACOLOGICA SINICA (2018)

Review Oncology

Mechanisms of therapeutic CDK4/6 inhibition in breast cancer

Susan Combs Scott et al.

SEMINARS IN ONCOLOGY (2017)

Article Cell Biology

Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2

Pierangela Totta et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Article Biochemical Research Methods

Combenefit: an interactive platform for the analysis and visualization of drug combinations

Giovanni Y. Di Veroli et al.

BIOINFORMATICS (2016)

Review Oncology

Endocrine treatment in breast cancer: Cure, resistance and beyond

Konstantinos Tryfonidis et al.

CANCER TREATMENT REVIEWS (2016)

Article Multidisciplinary Sciences

Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation

Pierangela Totta et al.

SCIENTIFIC REPORTS (2016)

Article Chemistry, Medicinal

Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells

Daniel M. Rotroff et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2013)

Article Biochemistry & Molecular Biology

Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity

Adam S. Potter et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Endocrine Therapy of Breast Cancer

F. Lumachi et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Genetics & Heredity

FOXA1 is a key determinant of estrogen receptor function and endocrine response

Antoni Hurtado et al.

NATURE GENETICS (2011)

Article Developmental Biology

FOXA1 is an essential determinant of ERα expression and mammary ductal morphogenesis

Gina M. Bernardo et al.

DEVELOPMENT (2010)

Review Biochemistry & Molecular Biology

Telaprevir: A Promising Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

I. Gentile et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Noritaka Yamaguchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Genetics & Heredity

Genome-wide analysis of estrogen receptor binding sites

Jason S. Carroll et al.

NATURE GENETICS (2006)

Article Biochemical Research Methods

Analysis of apoptosis by propidium iodide staining and flow cytometry

Carlo Riccardi et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response

J Laganière et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)