Journal
MOLECULAR NEUROBIOLOGY
Volume 59, Issue 10, Pages 5935-5954Publisher
SPRINGER
DOI: 10.1007/s12035-022-02944-x
Keywords
Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; Biomarkers; Magnetic resonance imaging; Positron emission computed tomography; Diagnosis
Categories
Funding
- National Natural Science Foundation of China [81903829]
- Luzhou Municipal People's Government [2018LZXNYD-ZK42]
- Southwest Medical University, China [2018LZXNYD-ZK42]
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Neurodegenerative diseases are characterized by progressive degeneration, brain tissue damage, and neuronal loss, accompanied by behavioral and cognitive dysfunctions. MRI has become an advanced medical imaging technique widely used in the clinical examination of NDs, playing a crucial role in the early diagnosis and treatment.
Neurodegenerative diseases (NDs), including chronic disease such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis, and acute diseases like traumatic brain injury and ischemic stroke are characterized by progressive degeneration, brain tissue damage and loss of neurons, accompanied by behavioral and cognitive dysfunctions. So far, there are no complete cures for NDs; thus, early and timely diagnoses are essential and beneficial to patients' treatment. Magnetic resonance imaging (MRI) has become one of the advanced medical imaging techniques widely used in the clinical examination of NDs due to its non-invasive diagnostic value. In this review, research published in English in current decade from PubMed electronic database on the use of MRI to detect specific biomarkers of NDs was collected, summarized, and discussed, which provides valuable suggestions for the early diagnosis, prevention, and treatment of NDs in the clinic.
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