4.6 Article

Differential Gene Expression in Sporadic and Genetic Forms of Alzheimer's Disease and Frontotemporal Dementia in Brain Tissue and Lymphoblastoid Cell Lines

Related references

Note: Only part of the references are listed.
Review Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

Alberto Serrano-Pozo et al.

Summary: The APOE ε4 allele and ε2 allele are respectively the strongest genetic risk factor and protective factor for Alzheimer's disease. While therapies targeting APOE are currently unavailable, recent research has expanded our understanding of APOE pathogenesis to include multiple pathological processes, offering valuable insights for therapy development.

LANCET NEUROLOGY (2021)

Article Multidisciplinary Sciences

Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer's Disease

Travis S. Johnson et al.

Summary: This study analyzed transcriptomic data from AD brains and found that the increased expression of microglia modules in AD samples was due to increased microglia proportions, while the decreased expression and perturbed co-expression within neuron modules were likely related to impaired neuronal pathways. Differentiated expression of transcription factors may account for altered gene regulation in AD. The changes in gene expression and co-expression within astrocyte modules could be attributed to both astrogliosis and astrocyte gene activation.

SCIENTIFIC REPORTS (2021)

Review Neurosciences

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Ayush Noori et al.

Summary: The study found a common pan-neurodegenerative gene expression signature across neurodegenerative disorders like AD, LBD, and ALS-FTD, characterized by upregulation of innate immunity, cytoskeleton, and transcription genes, as well as downregulation of the mitochondrial electron transport chain. Pathway enrichment analyses also indicated neuroinflammation, phagocytosis, and disruptions in energy metabolism and protein degradation systems as consistent features underlying these diseases.

NEUROBIOLOGY OF DISEASE (2021)

Article Neurosciences

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Nuole Zhu et al.

Summary: This study found that plasma GFAP and plasma neurofilament light chain levels differ in frontotemporal dementia and Alzheimer's disease, and their combination is useful for distinguishing between the two diseases. In FTD patients, plasma GFAP is correlated with cognition, CSF and plasma NfL, and cortical thickness. Higher tertile of plasma GFAP is associated with greater cognitive decline during follow-up in FTD and AD patients.

TRANSLATIONAL NEURODEGENERATION (2021)

Article Multidisciplinary Sciences

Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer's disease

Angela M. Crist et al.

Summary: Selective vulnerability of different brain regions is observed in many neurodegenerative disorders, with the hippocampus and cortex being particularly affected in Alzheimer's disease (AD). By studying postmortem tissue, researchers were able to identify gene expression changes associated with hippocampal vulnerability in AD, as well as genes related to AD neuropathology through machine learning. Further analysis suggested a relationship between SERPINA5 expression and tau expression in the brain.

NATURE COMMUNICATIONS (2021)

Review Behavioral Sciences

The transcriptional landscape of Alzheimer's disease and its association with Wnt signaling pathway

Milka Martinez et al.

Summary: Alzheimer's disease is a neurological disorder that primarily affects the elderly, characterized by progressive cognitive decline and loss of autonomy. Transcriptional changes in susceptible signaling pathways, particularly the Wnt signaling pathway, have been linked to synaptic dysfunction and neuronal degeneration, highlighting synapse failure as a key pathological event in early stages of the disease.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

Review Neurosciences

The biological pathways of Alzheimer disease: a review

Marco Calabro et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects older individuals, with a rapidly increasing number of cases worldwide. The exact molecular events and biological pathways underlying the disease are still unknown, despite research on its biological and genetic components.

AIMS NEUROSCIENCE (2021)

Article Genetics & Heredity

Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer's disease in genes and isoforms

Cong Fan et al.

Summary: Alzheimer's disease (AD) is a common neurodegenerative disease caused by multiple factors with limited mechanistic insight. This study identified 29 co-expression modules in brain tissues of AD patients, with two isoform modules enriched with AD-associated SNPs and genes. The analysis suggests potential AD-related co-expression networks and identifies drugs for restoring gene expression towards health.

HUMAN GENETICS (2021)

Article Biochemistry & Molecular Biology

The reactome pathway knowledgebase

Bijay Jassal et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Clinical Neurology

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's

Fanny M. Elahi et al.

ALZHEIMERS & DEMENTIA (2020)

Article Biochemistry & Molecular Biology

Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders

Jose A. Santiago et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Neurosciences

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

Ian W. Weidling et al.

EXPERIMENTAL NEUROLOGY (2020)

Article Clinical Neurology

2020 Alzheimer's disease facts and figures

[Anonymous]

ALZHEIMERS & DEMENTIA (2020)

Article Medicine, Research & Experimental

NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease

Tobias Brummer et al.

EMBO MOLECULAR MEDICINE (2019)

Article Neurosciences

A Meta-Analysis of Alzheimer's Disease Brain Transcriptomic Data

Hamel Patel et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Immunology

Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains

Hamel Patel et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

Article Neurosciences

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dennis W. Dickson et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Article Clinical Neurology

Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP

Pol Andres-Benito et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2018)

Article Biochemical Research Methods

Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach

Ilijana Begcevic et al.

JOURNAL OF PROTEOMICS (2018)

Review Medicine, Research & Experimental

Gene networks in neurodegenerative disorders

Daniela Recabarren et al.

LIFE SCIENCES (2017)

Review Psychiatry

Genetic Biomarkers on Age-Related Cognitive Decline

Chieh-Hsin Lin et al.

FRONTIERS IN PSYCHIATRY (2017)

Review Cell Biology

The role of the immune system in Alzheimer disease: Etiology and treatment

Stefan Jevtic et al.

AGEING RESEARCH REVIEWS (2017)

Article Clinical Neurology

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

David C. Hondius et al.

ALZHEIMERS & DEMENTIA (2016)

Article Neurosciences

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease

Peixuan Pey et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

Michael H. Yan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Biochemistry & Molecular Biology

Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

Adriano Sebollela et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Neurosciences

Peripheral Mitochondrial Dysfunction in Alzheimer's Disease: Focus on Lymphocytes

Kristina Leuner et al.

MOLECULAR NEUROBIOLOGY (2012)

Article Cell Biology

Postmortem interval effect on RNA and gene expression in human brain tissue

Alex C. Birdsill et al.

CELL AND TISSUE BANKING (2011)

Article Biochemistry & Molecular Biology

Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

Daniah Trabzuni et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Review Clinical Neurology

Classification of primary progressive aphasia and its variants

M. L. Gorno-Tempini et al.

NEUROLOGY (2011)

Article Clinical Neurology

Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study

Pascal F. Durrenberger et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

Article Geriatrics & Gerontology

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

Winnie S. Liang et al.

NEUROBIOLOGY OF AGING (2010)

Article Mathematical & Computational Biology

QuickGO: a user tutorial for the web-based Gene Ontology browser

Rachael P. Huntley et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2009)

Article Biochemical Research Methods

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

Audrey Kauffmann et al.

BIOINFORMATICS (2008)

Article Biochemistry & Molecular Biology

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration

Alice S. Chen-Plotkin et al.

HUMAN MOLECULAR GENETICS (2008)

Article Geriatrics & Gerontology

Transcriptional profiling of Alzheimer blood mononuclear cells by microarray

Olivier C. Maes et al.

NEUROBIOLOGY OF AGING (2007)

Article Biotechnology & Applied Microbiology

Impact of RNA degradation on gene expression profiles:: Assessment of different methods to reliably determine RNA quality

Virginie Copois et al.

JOURNAL OF BIOTECHNOLOGY (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)