4.7 Review

The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation

Journal

MOLECULAR MEDICINE
Volume 28, Issue 1, Pages -

Publisher

SPRINGER
DOI: 10.1186/s10020-022-00510-8

Keywords

Liver failure; Cholestasis; Intensive care; Sepsis; Inflammation; Molecular medicine; Personalized medicine

Funding

  1. Interdisciplinary Centre for Clinical Research Jena [AMSP-05]
  2. German Research Foundation [316213987, Sonderforschungsbereich SFB1278]
  3. Projekt DEAL

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This review investigates the impact of dysregulated host response on the liver, consequences for the immune response, and potential avenues for personalized therapeutics.
Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits the host's ability to control the immune response appropriately, making it vulnerable to ineffective pathogen resistance and tissue damage. Deregulated networks of liver diseases are gradually uncovered by high-throughput, single-cell resolved OMICS technologies visualizing an astonishing diversity of cell types and regulatory interaction driving tolerogenic signaling in health and inflammation in disease. Therefore, this review elucidates the effects of the dysregulated host response on the liver, consequences for the immune response, and possible avenues for personalized therapeutics.

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