4.8 Editorial Material

TOPBPing up DSBs with PARylation

Journal

MOLECULAR CELL
Volume 82, Issue 14, Pages 2538-2540

Publisher

CELL PRESS
DOI: 10.1016/j.molcel.2022.06.038

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In this study, Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1 recruits Topoisomerase IIb-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.
Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIb-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.

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