Association of underlying comorbidities and progression of COVID-19 infection amongst 2586 patients hospitalised in the National Capital Region of India: a retrospective cohort study

This study is conducted to observe the association of diabetes (DM), hypertension (HTN) and chronic kidney disease (CKD) on the prognosis and mortality of COVID-19 infection in hospital admitted patients with above mentioned comorbidities. This is a single centre, observational, retrospective study carried out at Sir Ganga Ram Hospital, Delhi, India. The burden of comorbidities on the prognosis and clinical outcome of COVID-19 patients admitted patients from April 8, 2020, to October 4, 2020. Chi-square and relative risk test were used to observe the association of comorbidities and disease prognosis. A total of 2586 patients were included in the study consisting of 69.6% of male patients. All the comorbidities were significantly associated with ICU admission and mortality. The relative risk showed that CKD is most prone to severity as well as mortality of the COVID-19 infection followed by HTN and DM. Further with the increase in number of underlying comorbidities, the risk of ICU admission and mortality also increases. Relative risk of the severity of COVID-19 infection in younger patients with underlying comorbidities are relatively at higher risk of severity of disease as well as to mortality compared to the elderly patients with similar underlying condition. Similarly, it is found that females are relatively at higher risk of mortality as compared to the males having same comorbid conditions except for the hypertensive patients. Diabetes, hypertension and CKD, all are associated with progression of COVID-19 disease to severity and higher mortality risk. The number of underlying comorbid condition is directly proportional to the progression of disease severity and mortality.

Automated summary

This study examines the impact of diabetes, hypertension, and chronic kidney disease on the prognosis and mortality of COVID-19 infection. The results show that all comorbidities are significantly associated with ICU admission and mortality. CKD has the highest relative risk of severity and mortality, followed by hypertension and diabetes. The risk of ICU admission and mortality increases with the number of underlying comorbidities. Younger patients with underlying comorbidities are at higher risk of severity and mortality compared to elderly patients with similar conditions. Females also have a higher risk of mortality compared to males with the same comorbid conditions, except for hypertensive patients. Diabetes, hypertension, and CKD are all associated with the progression and higher mortality risk of COVID-19.