COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease

Article Immunology

The effect of colchicine on mortality outcome and duration of hospital stay in patients with COVID-19: A meta-analysis of randomized trials

Chia Siang Kow et al.

Summary: The use of colchicine in COVID-19 patients was associated with a significant reduction in hospital stay duration but did not show a significant impact on mortality rates.

IMMUNITY INFLAMMATION AND DISEASE (2022)

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Review Pathology

Immunopathology of Hyperinflammation in COVID-19

Joshua N. Gustine et al.

Summary: The rapid spread of COVID-19 has led to an unprecedented global public health crisis with recent studies suggesting that the hyperinflammatory syndrome induced by SARS-CoV-2 is a contributing factor to disease severity and mortality. Pathophysiological research shows that the hyperinflammatory syndrome in severe COVID-19 results from a dysregulated innate immune response. Current potential therapeutic approaches are being investigated to modulate the immune response and mitigate lung injury in severe COVID-19.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Review Allergy

Risk factors for severe and critically ill COVID-19 patients: A review

Ya-dong Gao et al.

Summary: The severity factors of COVID-19 include age, gender, underlying health conditions such as hypertension, diabetes, obesity, and immunodeficiency, which may lead to complications like acute kidney injury. Various laboratory indicators and parameters can help monitor disease progression, while socioeconomic factors, lifestyle, and quality of healthcare also play a role in individual outcomes.

ALLERGY (2021)

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Article Rheumatology

Amyloid storm: acute kidney injury and massive proteinuria, rapidly progressing to end-stage kidney disease in AA amyloidosis of familial Mediterranean fever

Olga L. Kukuy et al.

Summary: This study compared FMF amyloidosis patients who experienced an episode of amyloid storm with those who did not. It found that patients with amyloid storm were more likely to progress to ESRD or death in a shorter time period, with infections being the major triggers.

RHEUMATOLOGY (2021)

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Article Rheumatology

Defining colchicine resistance/intolerance in patients with familial Mediterranean fever: a modified-Delphi consensus approach

Seza Ozen et al.

Summary: A set of evidence-based core statements defining colchicine resistance/intolerance in patients with FMF were developed to guide clinicians and health authorities in the management of patients with FMF.

RHEUMATOLOGY (2021)

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Article Rheumatology

Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Anja Strangfeld et al.

Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Review Biochemistry & Molecular Biology

COVID-19 and the human innate immune system

Joachim L. Schultze et al.

Summary: The introduction of SARS-CoV-2 into the human population has led to a significant medical and economic crisis. Innate immunity plays a central role in combating the novel virus, with variability in its components contributing to the diverse disease courses observed for COVID-19. Further research into the pathophysiological mechanisms of innate immunity is crucial for the development of diagnostic markers and therapeutic strategies targeting COVID-19.

CELL (2021)

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Article Rheumatology

COVID-19 outcomes in patients with familial Mediterranean fever: a retrospective cohort study

Serdar Can Guven et al.

Summary: This study found an increased occurrence of comorbid diseases and IL-1 inhibitor usage in FMF patients hospitalized for COVID-19.

RHEUMATOLOGY INTERNATIONAL (2021)

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Article Rheumatology

Incidence and course of COVID-19 hospitalizations among patients with familial Mediterranean fever

Fadi Kharouf et al.

Summary: The study found no significant difference in the odds of hospitalization for COVID-19 between FMF patients and the non-FMF population, and similar disease severity and therapeutic approach in FMF COVID-19 inpatients and matched non-FMF COVID-19 inpatients.

RHEUMATOLOGY (2021)

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Article Rheumatology

The impact of COVID-19 on familial Mediterranean fever: a nationwide study

Zafer Gunendi et al.

Summary: This study evaluated the impact of COVID-19 in FMF patients and found that FMF may not be a risk factor for poor outcomes in COVID-19. Most FMF patients with COVID-19 had mild to moderate disease activity.

RHEUMATOLOGY INTERNATIONAL (2021)

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Article Immunology

COVID-19 Among Patients With Inflammatory Rheumatic Diseases

Sinem Nihal Esatoglu et al.

Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Rheumatology

Clinical course of COVID-19 in a cohort of 342 familial Mediterranean fever patients with a long-term treatment by colchicine in a French endemic area

Rim Bourguiba et al.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Review Medicine, General & Internal

Immune dysfunction in COVID-19 and judicious use of antirheumatic drugs for the treatment of hyperinflammation

Abdurrahman Tufan et al.

Summary: The novel Coronavirus 2019, which caused the coronavirus disease-19 (COVID-19) outbreak, had a significant impact globally, leading to the development and distribution of vaccines as a major milestone. However, treatment options for infected patients remain limited, with immune system dysregulation playing a crucial role in disease severity.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

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Article Medicine, General & Internal